Results 41 to 50 of about 4,369 (260)

Exploring the Therapeutic Potential of Mitragynine and Corynoxeine: Kratom-Derived Indole and Oxindole Alkaloids for Pain Management

Pharmaceuticals
The search for effective pain management solutions remains a critical challenge, especially amidst growing concerns over the use of conventional opioids.
Ahmed S. Alford, H. Moreno, Menny M. Benjamin, C. F. Dickinson, Mark T. Hamann   +4 more
semanticscholar   +1 more source

Kratom-induced Psychosis [PDF]

, 2020
Substance Use Disorder is a major concern for public health. Legal substances are often misused to get “high”. Beside the risk of developing subsequent mental health and physical conditions, one of major risk is related to behavioural changes leading to ...
Gary A Chaimowitz, Rizvi, Syed Ali, Syed Ali Rizvi, Prat, Sebastien S, Chaimowitz, Gary A, Sebastien S Prat   +5 more
core   +1 more source

From kratom to 7-hydroxymitragynine: evolution of a natural remedy into a public-health threat

Pharmaceutical Biology
Context Kratom (Mitragyna speciosa), native to Southeast Asia, has traditionally been consumed as fresh leaves or teas. Under those conditions, exposure to 7-hydroxymitragynine (7-OH)—a potent μ-opioid receptor agonist—is minimal, as it occurs only at ...
Scott Alsbrook, George Pro, Igor Koturbash   +2 more
semanticscholar   +1 more source

Understanding Kratom Use: A Guide for Healthcare Providers

Frontiers in Pharmacology, 2022
Kratom (Mitragyna speciosa Korth., Rubiaceae) is a plant native to Southeast Asia, where it has been used for centuries as a mild stimulant and as medicine for various ailments.
Marc T. Swogger, Kirsten E. Smith, Albert Garcia-Romeu, Oliver Grundmann, Oliver Grundmann, Charles A. Veltri, Jack E. Henningfield, Jack E. Henningfield, Lorna Y. Busch   +8 more
doaj   +1 more source

An update on the clinical pharmacology of kratom: uses, abuse potential and future considerations

Expert Review of Clinical Pharmacology
Introduction Kratom (Mitragyna speciosa) has generated substantial clinical and scientific interest as a complex natural product. Its predominant alkaloid mitragynine and several stereoisomers have been studied for activity in opioid, adrenergic, and ...
Christopher R. McCurdy, Abhisheak Sharma, Kirsten E. Smith, Charles A. Veltri, S. Weiss, Charles M. White, O. Grundmann   +6 more
semanticscholar   +1 more source

Growing pains with kratom: experiences discussed in subreddits contrast with satisfaction expressed in surveys

Frontiers in Pharmacology
Background“Kratom” refers to an array of bioactive products derived from Mitragyna speciosa, a tree indigenous to Southeast Asia. Most kratom consumers report analgesic and stimulatory effects, and common reasons for use are to address mental and ...
Jeffrey M. Rogers, Kayla Colvin, David H. Epstein, Oliver Grundmann, Christopher R. McCurdy, Kirsten E. Smith   +5 more
doaj   +1 more source

384 Motives for kratom self-medication: contents of public comments solicited by the FDA

Journal of Clinical and Translational Science, 2022
OBJECTIVES/GOALS: The present study sought to investigate kratom use motives among the U.S population with the goal of discovering previously unknown health-related reasons for kratom use by the general public.
Julia Tobacyk, Brian Parks, Lisa Brents
doaj   +1 more source

A Case of Kratom-induced Seizures [PDF]

Cureus, 2020
Kratom or Mitragna speciosa is a tropical tree that is indigenous to Southeast Asia, where it has been used for various medicinal reasons. In the West, it is used in the self-treatment of opioid withdrawal, pain, and a variety of mood and anxiety states.
Afzal, Hasnain, Esang, Michael, Rahman, Sabreen   +2 more
openaire   +2 more sources

Marketing features of derived intoxicating cannabinoid product brands on Instagram: A content analysis

Addiction, EarlyView.
Abstract Background and aims Use of derived intoxicating cannabinoid products (DICPs) has grown in the United States (US), as have associated poisonings, emergency department visits and psychotic episodes. Brand marketing on social media, a largely underregulated marketing channel, may be contributing to this growth.
Kathryn La Capria, Siyan Meng, Alisa A. Padon, Kayla K. Tillett, Scott I. Donaldson, Jon‐Patrick Allem, Matthew E. Rossheim, Cassidy LoParco, Carla J. Berg, Kristina M. Jackson, Julia Chen‐Sankey   +10 more
wiley   +1 more source

SCOOPING REVIEW: KEMATIAN KARENA KRATOM [PDF]

Latar Belakang: Kratom adalah tanaman famili kopi yang tumbuh subur di Asia Tenggara. Daun kratom tinggi dengan alkaloid mitraginin yang bersifat stimulansia.
Djunet, Nur Aini Aini Djunet
core   +1 more source