Results 101 to 110 of about 60,929 (294)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

AI-Enhanced Predictive Analytics in Optimizing Patient Outcomes within Pakistan's Healthcare System

AI integration in healthcare, particularly in low- and middle-income countries such as Pakistan, offers revolutionary opportunities by automating processes, analyzing data, and improving healthcare efficiency while addressing staffing and financial ...
Zehra, Maha, Humna Rafiq, Rafiq, Humna, Maha Zehra, Abid, Sidra, Sidra Abid   +5 more
core   +1 more source

Predictive Analytics in Information Systems Research [PDF]

, 2011
This research essay highlights the need to integrate predictive analytics into information systems research and shows several concrete ways in which this goal can be accomplished.
Shmueli, Galit, Koppius, Otto, Koppius, O.R. (Otto), Shmueli, G. (Galit), Shmueli, G   +4 more
core  

Predictive-prescriptive analytics for combustion monitoring in gas turbine power plants

, 2017
Why do many Predictive Maintenance systems fail? The proposition of Predictive Maintenance paradigm is that a failure of a give system can be expected and predicted.
Gassner, Martin, Bernero, Stefano, Kryszczuk, Krzysztof, Danafar, Somayeh   +3 more
core   +1 more source

Trends in null hypothesis significance testing: Still going strong

Heliyon
Null hypothesis significance testing (NHST) is among the most prominent and widely used methods for analyzing data. At the same time, NHST has been criticized since many years because of misuses and misconceptions that can be found extensively in the ...
Frank Emmert-Streib
doaj   +1 more source

The Cluster Variation Method: A Primer for Neuroscientists

Brain Sciences, 2016
Effective Brain–Computer Interfaces (BCIs) require that the time-varying activation patterns of 2-D neural ensembles be modelled. The cluster variation method (CVM) offers a means for the characterization of 2-D local pattern distributions.
Alianna J. Maren
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Mapping the future of medicine through digital twins

Frontiers in Molecular Medicine
Digital twins are rapidly gaining popularity in medicine and the health sciences, as they offer not merely a new method but a versatile paradigm capable of addressing a wide range of healthcare challenges.
Frank Emmert-Streib, Frank Emmert-Streib, Shailesh Tripathi, Shailesh Tripathi, Olli Yli-Harja, Olli Yli-Harja   +5 more
doaj   +1 more source

Comparing biological information contained in mRNA and non-coding RNAs for classification of lung cancer patients

BMC Cancer, 2019
Background Deciphering the meaning of the human DNA is an outstanding goal which would revolutionize medicine and our way for treating diseases. In recent years, non-coding RNAs have attracted much attention and shown to be functional in part.
Johannes Smolander, Alexey Stupnikov, Galina Glazko, Matthias Dehmer, Frank Emmert-Streib   +4 more
doaj   +1 more source