Results 111 to 120 of about 60,929 (294)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

A free boundary model for transport-induced neurite growth

European Journal of Applied Mathematics
We introduce a free boundary model to study the effect of vesicle transport onto neurite growth. It consists of systems of drift-diffusion equations describing the evolution of the density of antero- and retrograde vesicles in each neurite coupled to ...
Greta Marino, Jan-Frederik Pietschmann, Max Winkler   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Use of Predictive Analytics in Humanitarian Operations

, 2023
As humanitarian crises around the world intensify, there is a growing urge to find innovative solutions for humanitarian aid. One emerging solution is to use predictive analytics, a type of artificial intelligence, to predict the timing, scale, and scope
Jelonek, Aleksandra Christine
core  

Predicting early risk of chronic kidney disease in cats using routine clinical laboratory tests and machine learning

Journal of Veterinary Internal Medicine, 2019
Background Advanced machine learning methods combined with large sets of health screening data provide opportunities for diagnostic value in human and veterinary medicine.
Richard Bradley, Ilias Tagkopoulos, Minseung Kim, Yiannis Kokkinos, Theodoros Panagiotakos, James Kennedy, Geert De Meyer, Phillip Watson, Jonathan Elliott   +8 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Sequence-aware factorization machines for temporal predictive analytics

, 2020
In various web applications like targeted advertising and recommender systems, the available categorical features (e.g., product type) are often of great importance but sparse.
Wen-Chih Peng, Peng, Wen-Chih, Hongzhi Yin, Zhou, Xiaofang, Tong Chen, Quoc Viet Hung Nguyen, Li, Xue, Nguyen, Quoc Viet Hung, Yin, Hongzhi, Xiaofang Zhou, Xue Li, Peng, Wen Chih, Chen, Tong, Hung Nguyen, Quoc Viet   +13 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Embedding and operationalising predictive analytics in policing

This thesis examines the development and operational use of predictive analytics in policing. The extent to which predictive analytics has become embedded in policing is of fundamental importance to questions about the more specific use of predictive ...

core