Results 101 to 110 of about 1,686,261 (278)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

On the Coding of Negative Quantities in Cortical Circuits [PDF]

, 2008
Mullers Law of specific nerve energies introduced the idea that nerves transmit information about specific sensory features. This concept has been refined by the notion of 'labeled lines,' specific cells that capture sub-features of a sensory ...
Janneke Jehee, Dana H. Ballard, Dana Ballard   +2 more
core  

Codage des signaux par EMD [PDF]

, 2012
In this letter a new signals coding framework based on the Empirical Mode Decomposition (EMD) is introduced. The EMD breaks down any signal into a reduced number of oscillating components called Intrinsic Modes Decomposition (IMFs).
KHALDI, Kais, Boudraa, Abdelouahab, BOUDRAA, Abdel-Ouahab   +2 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Positive predictive values of the coding for bisphosphonate therapy among cancer patients in the Danish National Patient Registry

, 2012
Malene Schou Nielsson,1 Rune Erichsen,1 Trine Frøslev,1 Aliki Taylor,2 John Acquavella,2 Vera Ehrenstein11Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; 2Center for Observational Research International, Amgen
Nielsson MS, Frøslev T, Erichsen R, Ehrenstein V, Taylor A, Acquavella J   +5 more
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

A Humean challenge to predictive coding

, 2022
Presents a Humean challenge (via David Lewis) to predictive ...
Klein, Colin
core  

Transfer of predictive signals across saccades [PDF]

, 2012
Predicting visual information facilitates efficient processing of visual signals. Higher visual areas can support the processing of incoming visual information by generating predictive models that are fed back to lower visual areas.
Petra Vetter, Petra eVetter, Lars Muckli, Grace eEdwards, Grace Edwards, Vetter, P., Muckli, L., Edwards, G., Lars eMuckli   +8 more
core   +1 more source

A predictive coding account of bistable perception - a model-based fMRI study.

PLoS Computational Biology, 2017
In bistable vision, subjective perception wavers between two interpretations of a constant ambiguous stimulus. This dissociation between conscious perception and sensory stimulation has motivated various empirical studies on the neural correlates of ...
Veith Weilnhammer, Heiner Stuke, Guido Hesselmann, Philipp Sterzer, Katharina Schmack   +4 more
doaj   +1 more source