Results 61 to 70 of about 1,686,261 (278)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Emotional intentionality and predictive processing
Dialogues in Clinical Neuroscience & Mental Health, 2020 The detection and the prediction of changes of the world incorporate processes enabling an automatic coding of sameness. Predictions can be formed in relation to stimulus timing, location, or content, while it is not yet clear whether they concern a ...
Orestis Giotakos
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Predictive Encoding:: glazen bol of black box? [PDF]
, 2012 Het aantal digitale documenten in bedrijfsomgevingen neemt dermate toe dat men het beoordelen ervan niet kan overlaten aan experts. Met behulp van slimme software kan men de relevantie van elektronische documenten voorspellen.
Henseler, Hans
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Bidirectional predictive coding
CoRRPredictive coding (PC) is an influential computational model of visual learning and inference in the brain. Classical PC was proposed as a top-down generative model, where the brain actively predicts upcoming visual inputs, and inference minimises the prediction errors. Recent studies have also shown that PC can be formulated as a discriminative model,
Gaspard Oliviers +2 more
openaire +2 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Cerebral hierarchies: predictive processing, precision and the pulvinar. [PDF]
, 2015 This paper considers neuronal architectures from a computational perspective and asks what aspects of neuroanatomy and neurophysiology can be disclosed by the nature of neuronal computations?
Ryota Kanai (36890) +7 more
core
Backward adaptive pixel-based fast predictive motion estimation [PDF]
, 2009 This letter presents a novel backward adaptive pixel-based fast predictive motion estimation (BAPME) scheme for lossless video compression. Unlike the widely used block-matching motion estimation techniques, this method predicts the motion on a pixel-by ...
Canagarajah, CN +2 more
core +1 more source