Results 151 to 160 of about 18,935 (258)

Variable-Frequency Predictive Digital Current Mode Control

, 2008
—A variable-frequency predictive digital control method for the inductor current in switched-mode converters is introduced in this letter. This method is predictive in nature because the transistor off-time required for achieving the target current is ...
Dragan Maksimović, Student Member, Praneet Athalye, Robert Erickson   +3 more
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Asymmetric Modulated Predictive Current Control for Dual Three-Phase PMSM With Improved Performance

Dual three-phase PMSM (DTP-PMSM) has gained significant attention benefiting from their exceptional reliability and high torque density. However, DTP-PMSM exhibits poor steady-state performance and large calculation amount with the conventional finite ...
Zheng, Xingyu,, Gao, Xiaonan,, Li, Ze,, Zhang, Zhaoyan,, Xia, Jinhui,, Wang, Liling,, Liu, Hangan,, Liu, Zhiheng,, Rodriguez, Jose,   +8 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Reduced-sensor based Optimal-Switching-Sequence Model-Predictive-Current-Control for Grid-Tied Inverter with LCL filter

This paper presents an improved reduced-sensor based Optimal-Switching-Sequence Model-Predictive-Current-Control (OSS-MPCC) algorithm for a grid-tied inverter with LCL filter with only injected grid current measurements.
Saad Mekhilef (724278), Marif Daula Siddique (14425209), Mostefa Kermadi (20340984), Marizan Mubin (13513897), Mohammad Anas Anees (21184346)   +4 more
core  

Robust semi-explicit model predictive control for hybrid automata

, 2006
In this paper we propose an on-line design technique for the target control problem of hybrid automata. First, we compute on-line the shortest path, which has the minimum discrete cost, from an initial state to the given target set.
Spathopoulos, M.P., Xia, Hao, Xia, H., Pang, Yan, Spathopoulos, Michael P., Pang, Y.   +5 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Application effect of PMSM current segmented control method based on DM-MPCC algorithm

Scientific Reports
Given the issues of low accuracy and slow calculation speed in traditional PMSM current segmented control methods, this study proposes an improved model predictive current control method based on duty cycle modulation.
Shuai Ao
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source