Results 71 to 80 of about 2,294,849 (300)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Development and validation of age-specific predictive equations for total energy expenditure and physical activity levels for older adults. [PDF]

Am J Clin Nutr
Development and validation of age-specific predictive equations for total energy expenditure and physical activity levels for older ...
Porter J, Ward LC, Nguo K, Ward A, Davidson Z, Gibson S, Prentice R, Neuhouser ML, Truby H.   +8 more
europepmc   +2 more sources

Prediction equations for spirometry in South Africa

South African Medical Journal, 2013
The South African Guideline for Office Spirometry was recently published. Its aim was to provide an updated guideline for office spirometry in South Africa (SA), thereby improving the quality, standardisation and usefulness of spirometry. The need for local prediction equations based on large, all-inclusive studies of the SA population was highlighted ...
Koegelenberg, Coenraad F N, Swart, Francois, Irusen, Elvis M   +2 more
openaire   +3 more sources

Predictive performances of the limited sampling equations for AUC with various sampling time points.

, 2019
Predictive performances of the limited sampling equations for AUC with various sampling time points.
Eiji Kikuchi (794300), Eisuke Fujimoto (8115248), Yugo Shibagaki (745140), Koichiro Aida (8115245), Masahiko Yazawa (2822270), Hideo Sasaki (8115251), Yuichi Katsuoka (598446), Miki Yoshiike (8115239), Ryuto Nakazawa (8115236), Shiari Nozawa (8115242)   +9 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Predictive equations for estimating resting energy expenditure in women with overweight and obesity at three postpartum stages

Journal of Nutritional Science, 2020
The objective was to investigate which predictive equations provide the best estimates of resting energy expenditure (REE) in postpartum women with overweight and obesity.
Siri Halland Nesse, Inger Ottestad, Anna Winkvist, Fredrik Bertz, Lars Ellegård, Hilde K. Brekke   +5 more
doaj   +1 more source

New age-specific predictive equations for estimating resting metabolic rate of older adults

, 2023
New age-specific predictive equations for estimating resting metabolic rate of older ...
S Gibson (7757573), Judi Porter (13077099), L Ward (13610380), K Nguo (13350804), Z Davidson (13499290), R Prentice (13499293), H Truby (13350801), ML Neuhouser (15827828)   +7 more
core  

Performance of invasive (i.e. medical imaging and hand scans) and non-invasive (i.e. predictive equations) maturity indicators.

, 2023
Performance of invasive (i.e. medical imaging and hand scans) and non-invasive (i.e. predictive equations) maturity indicators.
Simon J. Roberts (7853666), Joseph Sullivan (6832106), John Mckeown (16955459), Martin Littlewood (9705578), Kevin Enright (9584809), Matthew Andrew (4922395), Christopher McLaren-Towlson (16955462)   +6 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source