Results 91 to 100 of about 2,166,973 (278)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Intermittent predictive control of an inverted pendulum [PDF]

, 2006
Intermittent predictive pole-placement control is successfully applied to the constrained-state control of a prestabilised experimental inverted ...
Gawthrop, P.J., Wang, L.
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MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Identification and predictive control of a multistage evaporator [PDF]

, 2010
A recurrent neural network-based nonlinear model predictive control (NMPC) scheme in parallel with PI control loops is developed for a simulation model of an industrial-scale five-stage evaporator.
Cao, Y., Tadé, M.O., J.C. Atuonwu, Rangaiah, G., Atuonwu, J.C., Atuonwu, James C., Cao, Yi, Rangaiah, G.P., Y. Cao, Atuonwu, J., Tade, Moses, Tadé, M. O., M.O. Tadé, G.P. Rangaiah, Rangaiah, G. P.   +14 more
core   +1 more source

The impact of different body surface area prediction equations on ventricular dilatation prevalence in youth soccer players

Frontiers in Cardiovascular Medicine
BackgroundThe normalization of echocardiographic variables for body surface area (BSA) enables to obtain relative indexes of ventricular size that are useful for diagnosis and monitoring of non-ischaemic cardiomyopathies.
Marco Alessandro Minetto, Elisabetta Toso, Federico Della Vecchia, Andrea Ferraris, Massimo Magistrali, Gianluca Alunni, Chiara Busso, Angelo Pietrobelli, Angelo Pietrobelli, John A. Shepherd, Steven B. Heymsfield   +10 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

New Predictive Equations for Resting Energy Expenditure in Normal to Overweight and Obese Population

International Journal of Endocrinology, 2019
Background and Aims. The unique demographic and dietary characteristics of modern Arabic population require development of a new predictive equation for the estimation of resting energy expenditure (REE). This study presented new equations characteristic
Ali M. Almajwal, Mahmoud M. A. Abulmeaty
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Validity of predictive equations for determining resting energy expenditure

, 2021
This bachelor thesis deals with the validation of predictive equations to determine resting metabolic rate. The objective of this bachelor thesis was to compare individual predictive equations for determining resting metabolic rate with self-measurement ...
Fabián, Patrik
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