Results 111 to 120 of about 9,698,228 (341)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Development of a new equation and validation of earlier resting energy expenditure predicting equations in adults living in Tehran [PDF]

Health Promotion Perspectives
Background: Predictive equations have been considered as a practical approach for estimating resting energy expenditure (REE) across multiple populations, but their accuracy for each community remains to be determined.
Yahya Jalilpiran, Neda Azizi, Kimia Alipoor, Sanaz Mehranfar, Mojdeh Ebaditabar, Sakineh Shab-Bidar, Alireza Ostadrahimi, Kurosh Djafarian   +7 more
doaj   +1 more source

Predictive Equations Regarding Coastal Transports

Coastal Engineering 1976, 1976
Morphological changes are the result of gradients in longshore and onshore-offshore sediment transport. The coastal engineer is continually faced with engineering problems in which a quantitative knowledge of these morphological changes is required.
openaire   +2 more sources

The Predictive Power of Ground‐Motion Prediction Equations [PDF]

Bulletin of the Seismological Society of America, 2017
Although model calibration should be always performed alongside model validation, this is rarely the case when deriving new ground‐motion prediction equations (GMPEs). Explanatory modeling (Shmueli, 2010) is often preferred to data‐driven predictive approaches, and the analysis of the residual distribution is generally used to support the model ...
openaire   +3 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Athlete or Non-athlete? This Is the Question in Body Composition

Frontiers in Physiology, 2021
Francesco Campa, Giuseppe Coratella
doaj   +1 more source

Residual Mechanical Behaviour and Constitutive Modelling of 6063-T5 Aluminium Alloy Under Different Cooling Conditions

Buildings
The residual mechanical properties after fire exposure form the basis for evaluating the structural performance of aluminium alloy components subjected to fire without collapse.
Ziheng Ding, Xuanyi Xue, Neng Wang, Shuai Li, Jianmin Hua   +4 more
doaj   +1 more source

Stochastic Optimal Prediction for the Kuramoto--Sivashinsky Equation [PDF]

Multiscale Modeling & Simulation, 2004
We examine the problem of predicting the evolution of solutions of the Kuramoto-Sivashinsky equation when initial data are missing. We use the optimal prediction method to construct equations for the reduced system. The resulting equations for the resolved components of the solution are random integrodifferential equations.
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Revised predictive equations for salt intrusion modelling in estuaries (discussion)

, 2015
For one-dimensional salt intrusion models to be predictive, we need predictive equations to link model parameters to observable hydraulic and geometric variables.
Nijzink, R.C. (author), Nijzink, R.C., Isabella Anak Gisen, J. (author), Isabella Anak Gisen, J., Savenije, H.H.G. (author), Savenije, H.H.G.   +5 more
core   +1 more source