Results 121 to 130 of about 9,698,228 (341)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Obtaining Microbiological and Pharmacokinetic Highly Predictive Equations
Current Topics in Medicinal Chemistry, 2018 In this paper, a Multilinear Regression (MLR) analysis has been carried out in order to accurately predict physicochemical properties and biological activities of a group of antibacterial quinolones by means of a set of structural descriptors called topological indices.
Bueso Bordils, José Ignacio +6 more
openaire +3 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Predictive equations overestimate the resting metabolic rate in postmenopausal women
, 2015 The resting energetic dispenses on postmenopausal stage should be well known in order to elaborate obesity prevention programs. The aim of this study was to compare the resting metabolic rate (RMR) measured by indirect calorimetry (RMRmeasured) with ...
Libardi, C A +12 more
core +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Model Identification and Robust Nonlinear Model Predictive Control of a Twin Rotor MIMO System
, 2009 PhDThis thesis presents an investigation into a number of model predictive control (MPC) paradigms for a nonlinear aerodynamics test rig, a twin rotor multi-input multi-output system (TRMS).
Rahideh, Akbar
core
, 2013 Predictive Equations Using Regression Analysis for the Developed and other Reference Equations Based on the Training Subset.
Yang Zhao (39052) +10 more
core +1 more source
Frontiers in Cardiovascular MedicineBackgroundThe normalization of echocardiographic variables for body surface area (BSA) enables to obtain relative indexes of ventricular size that are useful for diagnosis and monitoring of non-ischaemic cardiomyopathies.
Marco Alessandro Minetto +10 more
doaj +1 more source
Accuracy of predictive equations for estimating resting energy expenditure in obese adolescents.
Jornal de Pediatria, 2015 OBJECTIVE To compare resting energy expenditure (REE) measured by indirect calorimetry with REE predicted using different equations in obese adolescents.
M. Marra +7 more
semanticscholar +1 more source