Results 121 to 130 of about 2,294,849 (300)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

CRITICAL CONSIDERATIONS ON THE SINGLE VERTICAL JUMP TEST AS AN INDICATOR OF LOWER-LIMB POWER: PRELIMINARY FINDINGS

Studia Universitatis Babeş-Bolyai: Educatio Artis Gymnasticae
Introduction: The vertical jump test (VJT) is widely used to estimate lower-limb power through predictive equations, but the theoretical validity of these models remains uncertain.
Vlad Adrian GEANTĂ, Pierre Joseph DE HILLERIN   +1 more
doaj   +1 more source

Adjusted predictions for generalized estimating equations

Biometrics
ABSTRACT Generalized estimating equations (GEEs) are a popular statistical method for longitudinal data analysis, requiring specification of the first 2 marginal moments of the response along with a working correlation matrix to capture temporal correlations within a cluster.
Francis K C Hui, Samuel Muller, Alan H Welsh   +2 more
openaire   +2 more sources

Development and validation of new predictive equations for resting metabolic rate (RMR) of older adults, aged 65 years and over

, 2023
Development and validation of new predictive equations for resting metabolic rate (RMR) of older adults, aged 65 years and ...
Judi Porter (13077099), Ross Prentice (2954091), Marian L Neuhouser (15408077), Kay Nguo (5009105), Zoe Davidson (1225206), Helen Truby (2587669), Leigh C Ward (13412739), Simone Gibson (5009111)   +7 more
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Observation and prediction for the heat equation, III

Journal of Differential Equations, 1976
Dirichlet and Neumann data suffices. The pair (p), 9) cannot be specified arbitrarily, but we adopt the viewpoint that, in observation of an ongoing process, any consistency conditions are automatically satisfied; thus, we may assume that the observed pair (p), #) lies in the admissible manifold& and the existence of a solution to the triple (l)-(3 ...
openaire   +2 more sources

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Cross-validation of prediction equations for estimating body composition in ballet dancers.

PLoS ONE, 2019
INTRODUCTION:In sports related to low body weight, such as classical ballet, the assessment of body composition is important for monitoring performance and health status.
Leilane Lilian Araújo Leal, Giovanna Stefanne Lópes Barbosa, Rannapaula Lawrynhuk Urbano Ferreira, Erikarla Baracho Avelino, Adriana Nunes Bezerra, Sancha Helena de Lima Vale, Bruna Leal Lima Maciel   +6 more
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source