Results 131 to 140 of about 9,698,228 (341)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Prediction of Convergence Dynamics of Design Performance using Differential Recurrent Neural Networks [PDF]

, 2008
Computational Fluid Dynamics (CFD) simulations have been extensively used in many aerodynamic design optimization problems, such as wing and turbine blade shape design optimization.
Sendhoff, Bernhard, Yaochu Jin, Bernhard Sendhoff, Jin, Yaochu, Kowalczykiewicz, Michal, Yi Cao, Cao, Yi, Michal Kowalczykiewicz   +7 more
core   +1 more source

Basal Metabolic Rate of Adolescent Modern Pentathlon Athletes: Agreement between Indirect Calorimetry and Predictive Equations and the Correlation with Body Parameters

PLoS ONE, 2015
Purpose The accurate estimative of energy needs is crucial for an optimal physical performance among athletes and the basal metabolic rate (BMR) equations often are not well adjusted for adolescent athletes requiring the use of specific methods, such as ...
L. L. Loureiro, S. Fonseca, Natalia Casanova Castro, Renata Baratta dos Passos, Cristiana Pedrosa Melo Porto, A. P. Pierucci   +5 more
semanticscholar   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

CRITICAL CONSIDERATIONS ON THE SINGLE VERTICAL JUMP TEST AS AN INDICATOR OF LOWER-LIMB POWER: PRELIMINARY FINDINGS

Studia Universitatis Babeş-Bolyai: Educatio Artis Gymnasticae
Introduction: The vertical jump test (VJT) is widely used to estimate lower-limb power through predictive equations, but the theoretical validity of these models remains uncertain.
Vlad Adrian GEANTĂ, Pierre Joseph DE HILLERIN   +1 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Cross-validation of prediction equations for estimating body composition in ballet dancers.

PLoS ONE, 2019
INTRODUCTION:In sports related to low body weight, such as classical ballet, the assessment of body composition is important for monitoring performance and health status.
Leilane Lilian Araújo Leal, Giovanna Stefanne Lópes Barbosa, Rannapaula Lawrynhuk Urbano Ferreira, Erikarla Baracho Avelino, Adriana Nunes Bezerra, Sancha Helena de Lima Vale, Bruna Leal Lima Maciel   +6 more
doaj   +1 more source

Observation and prediction for the heat equation, III

Journal of Differential Equations, 1976
Dirichlet and Neumann data suffices. The pair (p), 9) cannot be specified arbitrarily, but we adopt the viewpoint that, in observation of an ongoing process, any consistency conditions are automatically satisfied; thus, we may assume that the observed pair (p), #) lies in the admissible manifold& and the existence of a solution to the triple (l)-(3 ...
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source