Results 91 to 100 of about 589,134 (276)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

International Journal of Prognostics and Health Management, ISSN 2153-2648, 2016 008 PHM-Based Wind Turbine Maintenance Optimization Using Real Options

International Journal of Prognostics and Health Management, 2016
A simulation-based real options analysis (ROA) approach is used to determine the optimum predictive maintenance opportunity for a wind turbine with a remaining useful life (RUL) prediction.
Xin Lei, Peter A. Sandborn
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Assessment of the Effect of Predictive Maintenance on the System Reliability

Vetor
In this work, we assess the effect of predictive maintenance on the reliability of repairable systems. In reparable systems, the reliability assessment considering corrective and preventive maintenance is well defined, but not considering predictive one.
Alexandre Santos Francisco, Marcos Vinícius Cardoso Lacerda, Luis Alberto Duncan Rangel   +2 more
doaj   +1 more source

Fleet Prognosis with Physics-informed Recurrent Neural Networks

, 2019
Services and warranties of large fleets of engineering assets is a very profitable business. The success of companies in that area is often related to predictive maintenance driven by advanced analytics.
Nascimento, Renato Giorgiani, Viana, Felipe A. C.   +1 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Cost-Effectiveness of Predictive Maintenance for Offshore Wind Farms: A Case Study

Energies
The successful implementation of predictive maintenance for offshore wind farms suffers from a poor understanding of the consequential short-term impacts and a lack of research on how to evaluate the cost-efficiency of such efforts.
Rasmus Dovnborg Frederiksen, Grzegorz Bocewicz, Grzegorz Radzki, Zbigniew Banaszak, Peter Nielsen   +4 more
doaj   +1 more source

Development Of Maintenance Policy Selection (MPS) Model To Select The Optimal Maintenance Policy For A System In Palm Oil Mill [PDF]

, 2010
The maintenance is change due to the development of technology. Under the changes, different maintenance policies have been developed, from corrective maintenance until predictive maintenance. Penyelenggaraan telah berubah dengan perkembangan teknologi.
Ding , Siew Hong
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source