Results 91 to 100 of about 595,998 (291)

Predictive Maintenance Servitisation Pathways

IFAC-PapersOnLine
The competition within the manufacturing industry is becoming increasingly intense in the Industry 4.0 era. Some manufacturers are transforming their traditional product-selling business model into product-service combos to gain customer loyalty and new sources of revenue through the so-called manufacturing servitisation.
Li, Jiahong, Milisavljevic-Syed, Jelena, Salonitis, Konstantinos   +2 more
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Cost-Effectiveness of Predictive Maintenance for Offshore Wind Farms: A Case Study

Energies
The successful implementation of predictive maintenance for offshore wind farms suffers from a poor understanding of the consequential short-term impacts and a lack of research on how to evaluate the cost-efficiency of such efforts.
Rasmus Dovnborg Frederiksen, Grzegorz Bocewicz, Grzegorz Radzki, Zbigniew Banaszak, Peter Nielsen   +4 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Critical Components Selection for a Prognostics and Health Management System Design: an Application to an Overhead Contact System [PDF]

, 2016
In recent years, improving quality of rail services by increasing availability, saving energy, and cutting the costs of infrastructure and rolling stock maintenance has become a central concern in the railway industry.
Brahimi, Mehdi, Leouatni, Mohammed, Medjaher, Kamal, Zerhouni, Noureddine   +3 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A literature review-based evaluation framework for maintenance strategy selection in heavy vehicles

Results in Engineering
Effective maintenance strategies are critical for ensuring operational reliability, minimizing downtime, and optimizing resource utilization in fleet-based industrial operations.
Malihe Goli, Behzad Ghodrati, Nick Eleftheroglou   +2 more
doaj   +1 more source

Exploring the Potential of Integrating Machine Tool Wear Monitoring and ML for Predictive Maintenance - A Review

Journal of Advanced Mechanical Sciences, 2023
This research review article explores the potential of integrating machine tool wear monitoring and ML algorithms for predictive maintenance. It synthesizes the latest research in the field, while discussing the benefits and challenges of various ...
S. Ganeshkumar
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A comprehensive review on artificial intelligence driven predictive maintenance in vehicles: technologies, challenges and future research directions

Discover Applied Sciences
Predictive maintenance has rapidly grown in automotive industries with the advancements in artificial intelligence (AI) technologies like machine learning, deep learning, and now generative AI.
Yashashree Mahale, Shrikrishna Kolhar, Anjali S. More   +2 more
doaj   +1 more source