Results 261 to 270 of about 1,308,678 (317)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Development and Validation of a Nomogram Predictive Model for Massive Ascites After Hepatectomy in Patients with Primary Hepatocellular Carcinoma. [PDF]

J Hepatocell Carcinoma
Men A, Sun D, Sun X, Jin L, Liu B, Chen F, Nan B, Wang W, Han L, Zhang W.   +9 more
europepmc   +1 more source

Implicit Non-convex Model Predictive Control [PDF]

, 2018
Gros, Sébastien,
core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Interpretable predictive model for listed companies ESG greenwashing based on XGBoost and SHAP. [PDF]

Sci Rep
Jianfeng Z, Tiantian Q.
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Enhancing respiratory virus surveillance among hospitalised children: a machine learning-based predictive model. [PDF]

BMJ Paediatr Open
Kant T, Datta RR, Farrar DS, Mtaweh H, Kaziev CL, Chen Y, Mahant S, Seaton C, Han M, Freire G, Campigotto A, Buchanan F, Morris SK, Gill PJ, READAPT-Kids Study.   +14 more
europepmc   +1 more source

Development and external validation of a predictive model for in-hospital mortality in patients with liver cirrhosis and sepsis. [PDF]

Sci Rep
Hu Y, Zhang L, Yin J.
europepmc   +1 more source