Results 211 to 220 of about 743,383 (345)

Epidemiology, Risk Factors, and Predictive Modelling of Post-Traumatic Sepsis: A Retrospective Cohort Study. [PDF]

Risk Manag Healthc Policy
Fu X, Wang ZY, Qin YJ, Cao XX, Deng WS, Dai C, Hu DZ, Dong SM.   +7 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Understanding resilience in medical interns through ecological momentary assessments, predictive modelling, and topic analysis. [PDF]

Commun Med (Lond)
Meine LE, McPherson EBA, Schmutz JB, Ruff CC, Käser L, HMZ STRESS Consortium, Kleim B.   +6 more
europepmc   +1 more source

Toward a two-scale modeling of spiral strand wire rope for floating offshore wind turbine to predict fatigue damages: possibilities and difficulties in using a legacy code

, 2018
Federico Bussolati, Olivier Allix, Pierre‐Alain Guidault, Martin Guiton, Yann Poirette   +4 more
openalex   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Predictive modelling and optimization of WEDM of nickel aluminium bronze alloy using optimised support vector regression and evolutionary algorithm. [PDF]

Sci Rep
Saha S, Modampuri SSR, Dutta H, Mallipeddi R, Nasan DS, Choudhury MR.   +5 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Analysis of risk factors and predictive modelling of biomarkers in subclinical hypothyroidism and implications for levothyroxine therapy in disease management. [PDF]

Sci Rep
Ghosh H, Biswas D, Pramanik S, Chowdhury S.   +3 more
europepmc   +1 more source

Sampled-data tracking under model predictive control and multi-rate planning: Further simulations and remarks

, 2019
Mohamed Elobaid, Mattia Mattioni, S. Monaco, D. Normand‐Cyrot   +3 more
openalex   +1 more source