Results 41 to 50 of about 874,956 (269)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Numerical simulation on prediction model of risk range of typical gas release through small holes

Meitan kexue jishu, 2023
In order to relieve the shortage of petroleum resources, it is a reasonable way to develop synthetic oil industry as a supplement of petroleum resources. In chemical synthesis, most reactions need to be carried out in pressurized environment.
ZHAO Kaigong, ZHANG Xiaolei, LI Zhangming, CHEN Gang, GAI Yongling   +4 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Evaluating RUL Predictive Models: A Risk-Based Predictive Maintenance Approach

AI
Remaining Useful Life (RUL) forecasting models are essential to enable predictive maintenance strategies. However, selecting the most appropriate model based solely on conventional accuracy metrics may be insufficient for practical decision making, where
Idriss El-Thalji, Ali Usman, Waqar Ali
doaj   +1 more source

Predicting the Survival of Primary Biliary Cholangitis Patients

Applied Sciences, 2022
Primary Biliary Cholangitis, which is thought to be caused by a combination of genetic and environmental factors, is a slow-growing chronic autoimmune disease in which the human body’s immune system attacks healthy cells and tissues and gradually ...
Diana Ferreira, Cristiana Neto, José Lopes, Júlio Duarte, António Abelha, José Machado   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Prediction of catastrophes: An experimental model [PDF]

Physical Review E, 2012
Catastrophes of all kinds can be roughly defined as short duration-large amplitude events following and followed by long periods of "ripening". Major earthquakes surely belong to the class of 'catastrophic' events. Because of the space-time scales involved, an experimental approach is often difficult, not to say impossible, however desirable it could ...
Peters, Randall D., Berre, Martine Le, Pomeau, Yves   +2 more
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Engineered human myogenic cells in hydrogels generate innervated vascularized myofibers within dystrophic mouse muscle on long-term engraftment

Cell Reports Medicine
Summary: Transplantation of human myogenic progenitor cells (MPCs) is a promising therapeutic strategy for treating muscle-wasting diseases, e.g., Duchenne muscular dystrophy (DMD).
Anna Kowala, James Boot, Jinhong Meng, Charles A. Mein, Olivier Pourquié, John T. Connelly, Jennifer E. Morgan, Yung-Yao Lin   +7 more
doaj   +1 more source