Results 91 to 100 of about 4,178,249 (281)

Extending predictive process monitoring for collaborative processes

CoRR
Process mining on business process execution data has focused primarily on orchestration-type processes performed in a single organization (intra-organizational). Collaborative (inter-organizational) processes, unlike those of orchestration type, expand several organizations (for example, in e-Government), adding complexity and various challenges both ...
Daniel Calegari, Andrea Delgado 0001
openaire   +2 more sources

Predictive Processing and the Representation Wars [PDF]

Minds and Machines, 2017
Clark has recently suggested that predictive processing advances a theory of neural function with the resources to put an ecumenical end to the "representation wars" of recent cognitive science. In this paper I defend and develop this suggestion. First, I broaden the representation wars to include three foundational challenges to representational ...
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Relative clause attachment in Mandarin Chinese: insights from classifier-noun agreement

Frontiers in Language Sciences
IntroductionPrevious studies have shown that relative clause (RC) attachment preferences vary across languages, often influenced by factors like morphosyntactic agreement (e.g., number and gender).
Fengming Liu, Chien-Jer Charles Lin
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An Active Inference Agent for Modeling Human Translation Processes

Entropy
This paper develops an outline for a hierarchically embedded architecture of an artificial agent that models human translation processes based on principles of active inference (AIF) and predictive processing (PP).
Michael Carl
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Optimal predictive control of water transport systems: Arrêt-Darré/Arros case study [PDF]

, 2009
This paper proposes the use of predictive optimal control as a suitable methodology to manage efficiently transport water networks. The predictive optimal controller is implemented using MPC control techniques.
Cardona, CM, Puig, Vicenc, Puig Cayuela, Vicenç, Chiron, Pascale, Trouvat, Jean-Luc, Romera Formiguera, Juli, Castro, A., Irizar, Ion, Charbonnaud, P, Castro, Alain, Chiron, P, Quevedo Casín, Joseba Jokin, Quevedo, Joseba, Charbonnaud, Philippe, Ayesa, E, Lujan, Mathias, Romera, Juli, Trouvat, J. L., Lujan, M, Salterain, Antonio, Irizar, I, Salterain, A., Cardona, Claudia, Ayesa, Eduardo   +23 more
core   +2 more sources