Results 111 to 120 of about 1,068,736 (293)

Drifting perceptual patterns suggest prediction errors fusion rather than hypothesis selection: replicating the rubber-hand illusion on a robot

, 2018
Humans can experience fake body parts as theirs just by simple visuo-tactile synchronous stimulation. This body-illusion is accompanied by a drift in the perception of the real limb towards the fake limb, suggesting an update of body estimation resulting
Cheng, Gordon, Hinz, Nina-Alisa, Lanillos, Pablo, Mueller, Hermann   +3 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Both symbolic and embodied representations contribute to spatial language processing: Evidence from younger and older adults [PDF]

, 2015
Building on earlier neuropsychological work, we adopted a novel individual differences approach to examine the relationship between spatial language and a wide range of both verbal and nonverbal abilities.
Coventry, Kenny, Fox, Chris, Markostamou, Ioanna, McInnes, Lynn   +3 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Prior probability cues bias sensory encoding with increasing task exposure

eLife
When observers have prior knowledge about the likely outcome of their perceptual decisions, they exhibit robust behavioural biases in reaction time and choice accuracy.
Kevin Walsh, David P McGovern, Jessica Dully, Simon P Kelly, Redmond G O'Connell   +4 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Predictive coding with spiking neurons and feedforward gist signaling

Frontiers in Computational Neuroscience
Predictive coding (PC) is an influential theory in neuroscience, which suggests the existence of a cortical architecture that is constantly generating and updating predictive representations of sensory inputs.
Kwangjun Lee, Shirin Dora, Shirin Dora, Jorge F. Mejias, Sander M. Bohte, Sander M. Bohte, Cyriel M. A. Pennartz   +6 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Psychotherapy as investigation: cultivating curiosity and insight in the therapeutic process

Frontiers in Psychology
Psychotherapy training and practice have grown increasingly complex, driven by expanding diagnostic frameworks, theoretical models, and intervention methods.
Judson A. Brewer, Judson A. Brewer, Fabio Giommi, Fabio Giommi   +3 more
doaj   +1 more source

The Problem of Mental Action [PDF]

, 2017
In mental action there is no motor output to be controlled and no sensory input vector that could be manipulated by bodily movement. It is therefore unclear whether this specific target phenomenon can be accommodated under the predictive processing ...
Metzinger, Thomas
core