Results 121 to 130 of about 4,178,249 (281)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Stimulus dependencies—rather than next-word prediction—can explain pre-onset brain encoding in naturalistic listening designs

eLife
The human brain is thought to constantly predict future words during language processing. Recently, a new approach emerged that aims to capture neural prediction directly by using vector representations of words (embeddings) to predict brain activity ...
Inés Schönmann, Jakub Szewczyk, Floris P de Lange, Micha Heilbron   +3 more
doaj   +1 more source

Predictive processing and cognitive development

, 2017
Philosophy and Predictive ...
openaire   +2 more sources

Embodied neuroaesthetics and the psychotherapeutic relational field

Frontiers in Psychology
Aesthetic experiences are bodily-anchored, posited to evoke profound emotional responses and advance development, mental health and well-being. This paper reviews and conceptually analyzes the embodied aesthetic experience and its imperative contribution
Sharon Vaisvaser
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Building Predictive Models in R Using the caret Package [PDF]

The caret package, short for classification and regression training, contains numerous tools for developing predictive models using the rich set of models available in R.
Max Kuhn
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A preliminary study of implicit statistical learning in non-clinical young adults exposed to early adversity

Frontiers in Psychiatry
BackgroundEarly adversity is associated with long-term alterations in learning and decision-making under uncertainty, yet its impact on implicit predictive processing remains insufficiently characterized.
Paweł Krukow, Natalia Kopiś-Posiej, Víctor Rodríguez-González, Víctor Rodríguez-González, Víctor Rodríguez-González, Víctor Gutiérrez-de Pablo, Víctor Gutiérrez-de Pablo, Víctor Gutiérrez-de Pablo, Carlos Gómez, Carlos Gómez, Carlos Gómez, Jesús Poza, Jesús Poza, Jesús Poza, Jesús Poza   +14 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Finger-tracking captures distinct cognitive signatures in L1 vs. L2 reading

Frontiers in Psychology
IntroductionPredictive and integrative mechanisms play a central role in real-time language comprehension. Understanding how native (L1) and non-native (L2) readers process linguistic information in real time is central to psycholinguistic research ...
Eva Polo, Claudia Marzi
doaj   +1 more source