Results 111 to 120 of about 797,608 (305)

Cross-Validated Bagged Prediction of Survival

Statistical Applications in Genetics and Molecular Biology, 2006
In this article, we show how to apply our previously proposed Deletion/Substitution/Addition algorithm in the context of right-censoring for the prediction of survival. Furthermore, we introduce how to incorporate bagging into the algorithm to obtain a cross-validated bagged estimator.
Sandra E, Sinisi, Romain, Neugebauer, Mark J, van der Laan   +2 more
openaire   +3 more sources

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Predicting and validating microRNA targets.

Genome biology, 2004
Given that microRNAs select their targets by nucleotide base-pairing, it follows that it should be possible to find microRNA targets computationally. There has been considerable progress, but assessing success and biological significance requires a move into the 'wet' lab.
openaire   +2 more sources

Validating Predictions from Climate Envelope Models

PLoS ONE, 2013
Climate envelope models are a potentially important conservation tool, but their ability to accurately forecast species' distributional shifts using independent survey data has not been fully evaluated. We created climate envelope models for 12 species of North American breeding birds previously shown to have experienced poleward range shifts. For each
James I Watling, David N Bucklin, Carolina Speroterra, Laura A Brandt, Frank J Mazzotti, Stephanie S Romañach   +5 more
openaire   +4 more sources

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

La Utilidad del Análisis de Grupos Estratégicos para la Identificación de Opciones Estratégicas de Éxito

Tec Empresarial, 2013
En el presente trabajo, tratamos de llevar a cabo unavaloración de lo que realmente puede aportar el análisis degrupos estratégicos, no sólo como herramienta de reflexiónestratégica, sino como un constructo válido para explicar lasdiferencias en la ...
Lorenzo Revuelto Taboada, Rafael Fernández Guerrero   +1 more
doaj  

Responses to traumatic brain injury screening questions and suicide attempts among those seeking Veterans Health Administration mental health services

Frontiers in Psychiatry, 2016
Background: Psychometrically sound screening tools available to aid in the identification of lifetime history of traumatic brain injury (TBI) are limited.
Alexandra Lindsay Schneider, Trisha Ann Hostetter, Beeta Yazmeen Homaifar, Beeta Yazmeen Homaifar, Beeta Yazmeen Homaifar, Jeri Erica Forster, Jeri Erica Forster, Jeri Erica Forster, Bridget Bulman Matarazzo, Bridget Bulman Matarazzo, Jennifer H. Olson-Madden, Jennifer H. Olson-Madden, Jennifer H. Olson-Madden, Joe eHuggins, Lisa Anne Brenner, Lisa Anne Brenner, Lisa Anne Brenner, Lisa Anne Brenner   +17 more
doaj   +1 more source

Onthological models predictively inequivalent to quantum theory

, 2013
Recently, it has been argued that no extension of quantum theory can have improved predictive power under a strong assumption of free choice of the experimental settings and validity of quantum mechanics.
Ghirardi, GianCarlo, Romano, Raffaele
core   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source