Results 91 to 100 of about 277,874 (307)

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Animal models as tools to study the pathophysiology of depression

Brazilian Journal of Psychiatry, 2013
The incidence of depressive illness is high worldwide, and the inadequacy of currently available drug treatments contributes to the significant health burden associated with depression.
Helena M. Abelaira, Gislaine Z. Reus, Joao Quevedo   +2 more
doaj   +1 more source

Validation of Maintainability Prediction. [PDF]

, 1982
Abstract : Validation of Maintainability Prediction Techniques prescribed in RADC-TR-78-169 was performed. The techniques for preliminary and detailed prediction were applied to three (3) representative samples of electronic equipment. The detailed predictions were then compared with demonstrated field performance on equipments that have in excess of ...
E. Edwards, J. Kubeck, W. DuBlanica
openaire   +1 more source

Knowledge tests for ab-initio pilot selction in civil aviation

, 2010
A validity study was conducted for two purposes: to evaluate the importance of knowledge tests for pilot selection and to validate the knowledge tests of the German Aerospace Center.
Zierke, Oliver
core  

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Intra-Session Reliability and Predictive Value of Maximum Voluntary Isometric Contraction for Estimating One-Repetition Maximum in Older Women: A Randomised Split-Sample Study

Journal of Functional Morphology and Kinesiology
Background: Ageing is associated with a progressive decline in muscle strength, particularly in the lower limbs, which compromises functional independence.
José Aldo Hernández-Murúa, Ena Monserrat Romero-Pérez, Jorge Luis Guajardo-Cruztitla, Blas Sinahí Madrigal Olivares, Ángel Gallego-Selles, Diego González-Martín, Francisca Reyes-Merino, Nidia Sánchez-García, José Antonio de Paz   +8 more
doaj   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Validity of the Emotional Intelligence Scale for use in sport

, 2009
This study investigated the factorial validity of the 33-item self-rated Emotional Intelligence Scale (EIS: Schutte et al., 1998) for use with athletes. In stage 1, content validity of the EIS was assessed by a panel of experts (n = 9).
Kevin A. Davies, Davies, Kevin A., Lane, A., Devonport, T., Gill, Gobinder S., Diehl, Caren D P, Caren D. P. Diehl, Gill, G., Neil Weston, Gobinder S. Gill, Thelwell, Richard, Devonport, Tracey J., Andrew M. Lane, Wilson, Mat, Richard Thelwell, Weston, Neil, Meyer, B., Mat Wilson, Meyer, Barbara B., Davies, K., Barbara B. Meyer, Diehl, C., Tracey J. Devonport, Lane, Andrew M.   +23 more
core  

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source