Results 71 to 80 of about 8,336,374 (303)
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Social and non-social directional cues differentially orient attention by learned habit
Frontiers in Human NeuroscienceIntroductionSince an early age, we are implicitly motivated to use the direction of eye gaze of others to learn about the environment, and we orient our attention in space based on this directional signal.
Claudia Salera +3 more
doaj +1 more source
Psychological Test Validity [PDF]
Современная зарубежная психология, 2015 This paper presents a theoretical overview of current aspects about the validity problems of psychological tests. The article demonstrates the importance of the development of psychological tests and the scientific studies of their validity, describes ...
Gessmann H.-W., Sheronov E.A.
doaj
Validation of Maintainability Prediction. [PDF]
, 1982 Abstract : Validation of Maintainability Prediction Techniques prescribed in RADC-TR-78-169 was performed. The techniques for preliminary and detailed prediction were applied to three (3) representative samples of electronic equipment. The detailed predictions were then compared with demonstrated field performance on equipments that have in excess of ...
E. Edwards, J. Kubeck, W. DuBlanica
openaire +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
BMC Public Health, 2015 BackgroundAs the understanding of how different aspects of the physical activity (PA) pattern relate to health and disease, proper assessment is increasingly important.
Ö. Ekblom +7 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Predictive validity in drug discovery: what it is, why it matters and how to improve it
Nature reviews. Drug discovery, 2022 J. Scannell +7 more
semanticscholar +1 more source
The Increasing Predictive Validity of Self-Rated Health
PLoS ONE, 2014 Using the 1980 to 2002 General Social Survey, a repeated cross-sectional study that has been linked to the National Death Index through 2008, this study examines the changing relationship between self-rated health and mortality.
Jason Schnittker, V. Baćak
semanticscholar +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source