Results 191 to 200 of about 18,186,110 (393)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Predictive value of tissue inhibitor of metalloproteinases-1 and carcinoembryonic antigen plasma levels in response to chemotherapy in patients with metastatic colorectal cancer

Journal of Research in Medical Sciences, 2014
Background: Colorectal cancer is one of the most important causes of morbidity and mortality in the world. It has been suggested that tissue inhibitor of metalloproteinase-1 (TIMP-1) plays a particular role in cancer promotion.
Mahnaz Roayaei, Hamid Emami, Pouria Adeli, Abbas Rezaei, Mojtaba Akbari   +4 more
doaj  

Positive Predictive Value of Gen-Probe APTIMA Combo 2 Testing for Neisseria gonorrhoeae in a Population of Women with Low Prevalence of N. gonorrhoeae Infection [PDF]

, 2004
Matthew R. Golden, James P. Hughes, L. E. Cles, K. Crouse, K. Gudgel, Jingrun Hu, Paul D. Swenson, Walter E. Stamm, H. Hunter Handsfield   +8 more
openalex   +1 more source

A Multicenter Study of the Predictive Value of Crescents in IgA Nephropathy.

Journal of the American Society of Nephrology, 2017
M. Haas, J. Verhave, Zhi-Hong Liu, Charles E. Alpers, J. Barratt, Jan U. Becker, D. Cattran, H. T. Cook, R. Coppo, J. Feehally, A. Pani, A. Perkowska-Ptasińska, Ian S D Roberts, Maria Fernanda Soares, H. Trimarchi, Su-xia Wang, Y. Yuzawa, Hong Zhang, S. Troyanov, R. Katafuchi   +19 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Coordination after gains and losses: Is prospect theory’s value function predictive for games? [PDF]

We analyze the effects of prior gain and loss experiences on individuals’ behavior in two coordination games: battle of the sexes and simultaneous market entry.
Krause, Kai Oliver, Schade, Christian, Schroeder, Andreas   +2 more
core   +1 more source

Strong predictive value of TIMI risk score analysis for in-hospital and long-term survival of patients with right ventricular infarction [PDF]

, 2002
R Gumina
openalex   +1 more source

Predictive Value of Small Dense Low-density Lipoprotein Cholesterol for Cardiovascular Events in Chinese Elder Diabetes Mellitus Patients [PDF]

, 2021
Xu Li, Xu Chen, Jingfen Lu, Yan Xu, Honglin Yang, Xuewen Zhou, Jianhong Xu, Hao Shen   +7 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Standardized predictive values

Journal of Magnetic Resonance Imaging, 2014
openaire   +3 more sources