Results 251 to 260 of about 924,200 (348)

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

open access: yesFEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay   +2 more
wiley   +1 more source

Diagnostic accuracy of ultrasonography for lower extremity arterial disease in patients with diabetes. [PDF]

open access: yesMedicine (Baltimore)
Zhao J   +6 more
europepmc   +1 more source

Feasibility of a field-based submaximal stair ascent test for estimating aerobic capacity and lower-limb strength in middle-aged and older adults. [PDF]

open access: yesClin Physiol Funct Imaging
Hyvärinen M   +7 more
europepmc   +1 more source

New proteomic biomarkers identified in plasma extracellular vesicles in sarcoidosis: a case-control matched study. [PDF]

open access: yesFront Immunol
Zhao R   +11 more
europepmc   +1 more source

Screening Program for Asymptomatic Hepatitis C: Uptake and Detection in the Marche Region of Italy. [PDF]

open access: yesJ Clin Med
Acuti Martellucci C   +13 more
europepmc   +1 more source

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