Directed evolution of enzymes at the crossroads of tradition and innovation
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
The influence of coach leadership behavior on athletes' prosocial behavior in sports: The mediating effect of goal orientation and moral disengagement in sports. [PDF]
Bu X +5 more
europepmc +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Diagnostic accuracy of ultrasonography for lower extremity arterial disease in patients with diabetes. [PDF]
Zhao J +6 more
europepmc +1 more source
Feasibility of a field-based submaximal stair ascent test for estimating aerobic capacity and lower-limb strength in middle-aged and older adults. [PDF]
Hyvärinen M +7 more
europepmc +1 more source
New proteomic biomarkers identified in plasma extracellular vesicles in sarcoidosis: a case-control matched study. [PDF]
Zhao R +11 more
europepmc +1 more source
Screening Program for Asymptomatic Hepatitis C: Uptake and Detection in the Marche Region of Italy. [PDF]
Acuti Martellucci C +13 more
europepmc +1 more source
Association of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios With Three-Vessel Coronary Artery Disease: A Case-Control Study. [PDF]
Ayazkhoo L +5 more
europepmc +1 more source

