Results 41 to 50 of about 936,691 (247)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Severity of obstructive sleep apnea and its impact on coronary artery disease outcomes: A cross-sectional study in Egypt

Heart Vessels and Transplantation
Objectives: Coronary artery disease (CAD) and obstructive sleep apnea (OSA) share mechanisms such as intermittent hypoxia, inflammation, and sympathetic activation, worsening cardiac function and CAD severity. This study aimed to assess OSA prevalence in
Hossam Eldin M. Mahmoud, Ahmed Hussein, Esraa A. Taha, Eptehal M. Dongol, Ahmed G. Bakry   +4 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Factors associated with chronotype in individuals with bipolar disorder in remission

Indian Journal of Psychiatry
Background: Chronotype is trait-like construct reflecting long-term morningness–eveningness preferences. Higher eveningness scores are linked to sleep disturbances, night-eating, and addictive behaviors but remain understudied in subjects with bipolar ...
Ravneet Singh, Raman Deep, Vaibhav Patil, Rachna Bhargava, Ashwani Kumar Mishra   +4 more
doaj   +1 more source

The status and predictors of self‐care among older adults with hypertension in China using the Chinese version of Self‐Care of Hypertension Inventory – A cross‐sectional study

Nursing Open, 2022
Aim To investigate the status and predictors of self‐care among older adults with hypertension in China by the Chinese version of Self‐Care of Hypertension Inventory. Design A cross‐sectional questionnaire survey.
Yu‐Jie Guo, Xiao‐Yun Hu, Hong‐Juan Ji, Qiao Zhao, Long‐Yuan Wang, Xiao‐Yan Zhou, Jue Tang, Lei Yang, Xiang‐Chao Sun   +8 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Suture-Mediated Patent Fossa Ovalis Closure

JACC: Advances
Background: At short-term follow-up, percutaneous suture-mediated patent fossa ovalis (PFO) closure appears as a safe and effective alternative to device-based methods.
Achille Gaspardone, MD, MPhil, Gregory A. Sgueglia, MD, PhD, Antonella De Santis, MD, Fabiana Piccioni, MD, Emanuela D’Ascoli, MD, Tommasa Siragusa, RCIS, Maria Iamele, MD, Maria Benedetta Giannico, MD, Fabrizio D’Errico, MD, Carlo Gaspardone, MD   +9 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Health-related quality of life and its determinants in patients with migraine relating to the coronavirus disease 2019 pandemic in the Eastern Province of Saudi Arabia

Journal of Family and Community Medicine
BACKGROUND: Migraine is a neurological disorder associated with different levels of disability that can impact health-related quality of life (HRQoL).
Dhafer Alshayban
doaj   +1 more source