Results 51 to 60 of about 32,530 (244)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Frontiers in Cellular and Infection Microbiology, 2020 Mycobacterium tuberculosis (Mtb) synthesizes a variety of atypical lipids that are exposed at the cell surface and help the bacterium infect macrophages and escape elimination by the cell's immune responses.
Jacques Augenstreich +10 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
PLoS ONE, 2020 BackgroundAlthough mood stabilizers such as lithium (LIT), valproate (VAL), and lamotrigine (LMT) appear to be efficacious treatments for bipolar disorder (BD) in research settings, the long-term response to these mood stabilizers in clinical practice is
Young Sup Woo +12 more
doaj +1 more source
Annals of General Psychiatry, 2023 Background Despite a high number of studies investigating the correlation between long Duration of Untreated Illness (DUI) and poor course of Bipolar Disorder (BD), the results concerning the impact of DUI on some specific factors, such as suicidality ...
Gabriele Di Salvo +4 more
doaj +1 more source
Predominant Th2/Tc2 Polarity of Tumor-Infiltrating Lymphocytes in Human Cervical Cancer [PDF]
The Journal of Immunology, 2001 Abstract Cytotoxic T lymphocytes (Tc) play a central role in cellular immunity against cancers. The cytotoxic potential of freshly isolated tumor-infiltrating lymphocytes (TILs) is usually not expressed. This suggests the possible existence of as yet unspecified and perhaps complex immunosuppressive factors or cytokines that affect ...
B C, Sheu +5 more
openaire +2 more sources
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Research Progress on PATJ and Underlying Mechanisms Associated with Functional Outcomes After Stroke
Neuropsychiatric Disease and Treatment, 2021 Wen-Jie Wang,1 Tian-Jie Lyu,2,3 Zixiao Li1– 5 1Vascular Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People’s Republic of China; 2China National Clinical Research Center for Neurological ...
Wang WJ, Lyu TJ, Li Z
doaj
Influence of Solvent Polarity on the Kinetics of Microwave-assisted Extraction, Composition, and Antiradical Activity of Black Locust Flowers (Robinia pseudoacacia flos) Extracts [PDF]
Chemical and Biochemical Engineering QuarterlyThe present study investigated the influence of solvent polarity on the kinetics of microwave-assisted extraction of phenolic compounds from black locust flowers.
I. M. Savic +2 more
doaj +1 more source