Results 121 to 130 of about 2,501,837 (301)

Is more health always better? Exploring public preferences that violate monotonicity [PDF]

open access: yes, 2009
Abásolo and Tsuchiya (2004a) report on an empirical study to elicit public preferences regarding the efficiency-equality trade-off in health, where the majority of respondents violated monotonicity.
Abásolo, I., Tsuchiya, A.
core  

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

open access: yesFEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao   +3 more
wiley   +1 more source

Euclidean preferences [PDF]

open access: yes
Cette note est consacrée à la question:Quelle restriction impose-t-on en faisant l'hypothèse qu'un profil de préférences est euclidien en dimension d ?
Anna Bogomolnaïa   +1 more
core  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

PREFERENCES OF POTENTIAL APPLICANTS FOR UNIVERSITY EDUCATION AND THE “LEARNING ECONOMY”

open access: yesJournal on Efficiency and Responsibility in Education and Science, 2011
In the current postmodern society, knowledge is still more important. Also corresponding with this fact are the development theories which have been developed from the theory of learning organisation, the theory of learning regions to the relatively new ...
Jaku Husák, Markéta Volkánová
doaj  

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Effects of a school-based intervention program for adolescents with a special focus on the overweight/obese population [Efekty školního intervenčního programu pro adolescenty se zaměřením na populaci s nadváhou/obezitou]

open access: yesActa Universitatis Palackianae Olomucensis. Gymnica, 2011
BACKGROUND: Obesity has become a pandemic, with more than a billion people affected worldwide. During the past two decades, the prevalence of obesity in children has risen greatly throughout the entire world.
Michal Kudláček, Lisa Carla James
doaj  

Distinguishing Social Preferences from Preferences for Altruism [PDF]

open access: yes
We report a laboratory experiment that enables us to distinguish preferences for altruism (concerning tradeoffs between own payoffs and the payoffs of others) from social preferences (concerning tradeoffs between the payoffs of others).
Daniel Markovits   +2 more
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

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