Results 101 to 110 of about 2,501,837 (301)

Climate services bundles preferences of smallholder farmers in West Africa: a stated choice modelling

Frontiers in Climate
This study investigates the preferences of rainfed farmers in West Africa for bundled agroclimate services, addressing challenges posed by climate variability and limited purchasing power.
Adama Ouedraogo, Adama Ouedraogo, Adama Ouedraogo, Mathieu Ouedraogo, Mathieu Ouedraogo, Irene S. Egyir, Peter Läderach, Akwasi Mensah-Bonsu, John Baptist D. Jatoe   +8 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Comparison of milk consumption habits across two European countries: Pilot study in Portugal and France

Open Agriculture
Humans have been consuming milk obtained from domesticated animals since ancient times. Milk is a very complete food with important nutrients that can support life. However, the patterns of consumption of milk have been shifting.
Guiné Raquel P. F., Florença Sofia G., Bréjon Marius, Gonçalves João Carlos, Barroca Maria João, Ferreira Manuela, Fragata Anabela   +6 more
doaj   +1 more source

Preferences of Hospital Pharmacists for the Different Attributes of Intravitreal Treatments for Neovascular Age-Related Macular Degeneration and Diabetic Macular Edema in Spain: The SEEKING Study

Pharmacy
The process of evaluation and selection of drugs in Spain is currently changing, with hospital pharmacists (HPs) having a growing relevance. This cross-sectional observational study aimed to assess HPs’ preferences for different hypothetical intravitreal
José Luis Poveda, Pablo Arnáiz, Silvia López, Belén Muñoz, Anxo Fernández-Ferreiro   +4 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Bridging the gap between paediatric to adult care: experiences with the transition of adolescents with chronic conditions in the Netherlands

International Journal of Integrated Care, 2009
AnneLoes van Staa, Susan Jedeloo, Marij E. Roebroeck, Jos M. Latour   +3 more
doaj   +3 more sources

PENGARUH NILAI DAN GAYA HIDUP TERHADAP PREFERENSI DAN PERILAKU PEMBELIAN BUAH-BUAHAN IMPOR

Jurnal Ilmu Keluarga dan Konsumen, 2013
This study was intended to determine the influence of values and lifestyle on the preferences and purchasing behavior of imported fruits. This study applied cross sectional design and involved 60 housewives which were randomly selected.
Astari Sukmaningtyas, Hartoyo Hartoyo
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source