Results 141 to 150 of about 211 (203)

Integrative in silico and in vitro screening of small molecules targeting RNA

Current Protocols, Volume 6, Issue 8, August 2026.
Abstract Targeting structured RNA elements with small molecules has emerged as a promising yet technically challenging strategy for antiviral drug discovery. Here, we present a comprehensive and experimentally validated workflow for the integrative in silico and in vitro screening of RNA‐binding small molecules.
Sabrina Toews, Megan Ken, Harald Schwalbe   +2 more
wiley   +1 more source

The Complete Chloroplast Genome Sequences of Salvia reflexa and Genome Comparison: Implications for Phylogeny and Plant Invasion

Ecology and Evolution, Volume 16, Issue 8, August 2026.
This study reports the complete chloroplast genome of Salvia reflexa and compares it with those of other invasive and non‐invasive Salvia species to explore genomic features associated with invasiveness. The chloroplast genome exhibits a typical quadripartite structure and shows high conservation within the genus, while several hypervariable regions ...
Lina Ding, Tianhe Yang, Shuai Wang, Hanyue Zhou, Ran Xin, Qing Miao, Ping Guan, Bo Qu   +7 more
wiley   +1 more source

Strategic Development of the Genetic Counselor Profession in Germany, Austria, and Switzerland: The Establishment of the GfH Genetic Counselor Commission

Journal of Genetic Counseling, Volume 35, Issue 4, August 2026.
ABSTRACT In June 2024, the German Society of Human Genetics (GfH) established a commission for Genetic Counselors (German translation: Genetische Fachberater:innen) with 86% members' approval, marking a significant step for the genetic counselor profession in Germany, Austria, and Switzerland (D‐A‐CH).
Gunda Schwaninger, Simone Heidemann, Kathrin Taxer, Sabine Rudnik‐Schöneborn, Johannes Zschocke   +4 more
wiley   +1 more source

Pre‐Imaging Clinical Factors Associated With Cardiac MR Image Quality Using Large Language Model‐Enabled Data Extraction

Journal of Magnetic Resonance Imaging, Volume 64, Issue 2, Page 565-578, August 2026.
ABSTRACT Background Poor cardiac MR image quality can prompt repeat examinations and hinder clinical decision‐making. Purpose To evaluate whether pre‐imaging clinical information, extracted using a large language model (LLM), is independently associated with cardiac MR image quality. Study Type Retrospective.
Hong Yu, Masha Bondarenko, Ali Nowroozi, Yoo Jin Lee, Adrian Serapio, Punita Kaveti, Jae Ho Sohn   +6 more
wiley   +1 more source

Predictors and Outcomes of 30‐Day Readmissions Following Electrical Cardioversion for Atrial Fibrillation: Insights From the Nationwide Readmissions Database

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
Among 134 114 atrial fibrillation hospitalizations treated with electrical cardioversion in the 2016–2017 NRD, 9.9% resulted in 30‐day readmission. Readmission was associated with higher mortality, longer stay and greater costs. Predictors included cardiometabolic comorbidities, female sex, lower income, Medicare/Medicaid insurance, nonhome discharge ...
Adeena Jamil, Muhammad Umer Sohail, Asad Ali Ahmed Cheema, Syed Usama Ashraf, Anushah Faheem Ilyas, Faizan Abbas, Shaikh Jehanzaib Saeed, Mohammad Rayyan Faisal, Ahmad Murtaza Anwar, Shanzey Rai, Syeda Unzila Tirmizi, Muhammad Uzair, Tooba Shahzad   +12 more
wiley   +1 more source

Inhibiting the Endothelial Mechanosensitive Channel Piezo1 Restores Hippocampal Blood–Brain Barrier Integrity to Improve Anesthesia‐ and Surgery‐Induced Cognitive Decline

MedComm, Volume 7, Issue 8, August 2026.
Approximately 10%–30% of elderly patients develop cognitive decline after surgery. How brain regions coordinate cellular networks to mediate this remains unclear. Anesthesia/surgery induces Piezo1 in hippocampal endothelial cells of aged mice. Endothelial Piezo1 deletion restores BBB integrity and improves cognition.
Yong Qiu, Chunheng Mo, Jinyan Wu, Jiachen Li, Shiyu Xu, Lu Chen, Liyin Zhang, Xingming Huang, Yi Zhang, Meng Sun, Yi Kang, Tao Zhu, Bi‐Sen Ding, Guo Chen   +13 more
wiley   +1 more source

Restriction‐Weighted Q‐Space Trajectory Imaging (ResQ): Toward Mapping Diffusion‐Time Effects With Tensor‐Valued Diffusion Encoding in Human Prostate Cancer Xenografts

NMR in Biomedicine, Volume 39, Issue 8, August 2026.
Tensor‐valued diffusion MRI enables microstructure characterization but can be confounded by the presence of restricted diffusion. We introduce ResQ, a framework that incorporates restriction weighting into q‐space trajectory imaging and we evaluate it in a longitudinal study of prostate cancer xenografts treated by external radiotherapy. ResQ revealed
Filip Szczepankiewicz, Malwina Molendowska, Samo Lasič, Marcella E. Safi, Michael Gottschalk, Evangelia Sereti, Anders Bjartell, Linda Knutsson, Oskar Vilhelmsson Timmermand, Crister Ceberg, Joanna Strand   +10 more
wiley   +1 more source

Leveraging Administrative Health Data to Capture Rare Adverse Drug Reactions: Identifying Pediatric Patients With Trimethoprim‐Sulfamethoxazole Acute Respiratory Distress Syndrome

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Rare adverse drug reactions (ADRs) are underrecognized and underreported in the electronic medical record (EMR). These events often require clinical review, making systematic identification challenging. The study aim was to develop an approach to prioritize identification and validation of a rare ADR to trimethoprim‐sulfamethoxazole causing ...
Keith Feldman, Jenna O. Miller, Katherine Doane, Laura Loftis, James W. Antoon, Kevin J. Downes, Jennifer L. Goldman   +6 more
wiley   +1 more source

Buffering Effects of Physical Activity on Negative Life Events–Life Satisfaction Dynamics

Stress and Health, Volume 42, Issue 4, August 2026.
ABSTRACT This study investigated whether physical activity buffers the association between negative life events and life satisfaction, distinguishing between dependent (e.g., divorce) and independent (e.g., bereavement) stressors as well as within‐ and between‐person processes across one‐ and 2‐year intervals (indicating short‐ and medium‐term ...
Daniel Groß, Jasmin Haffa, Wenke Möhring   +2 more
wiley   +1 more source

Converting an Integer to a Decimal String in Under Two Nanoseconds

Software: Practice and Experience, Volume 56, Issue 8, Page 963-977, August 2026.
ABSTRACT Objective Converting binary integers to variable‐length decimal strings is a fundamental operation in computing. Conventional fast approaches rely on recursive division and small lookup tables. The goal of this work is to develop a significantly faster method for this task.
Jaël Champagne Gareau, Daniel Lemire
wiley   +1 more source