Results 211 to 220 of about 591,591 (296)

Limbic Structural Alterations and Structural Covariance Across Prodromal Phenotypes and Early Parkinson's Disease

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Non‐motor symptoms may precede motor diagnosis in Parkinson's disease (PD), but whether distinct prodromal phenotypes exhibit differential limbic structural alterations remains unclear. Purpose To investigate limbic structural alterations across prodromal PD phenotypes defined by rapid eye movement sleep behavior disorder (RBD) and ...
Yuanyuan Zhao, Luoyu Wang, Yihan Suo, Maoling Liu, Yi Lin, Lidan Fang, Zhongxiang Ding   +6 more
wiley   +1 more source

Cell-Type-Specific Transcriptomic Alterations in the Epileptic Prefrontal Cortex and Complementary Neuroimaging Findings in an Independent Cohort. [PDF]

Cureus
Chen J, Ying Y, Wang C, Zhu Z, Lin J, Zhu J, Zheng Z.   +6 more
europepmc   +1 more source

Written exposure therapy augmented with transcranial direct current stimulation for posttraumatic stress disorder: A pilot randomized clinical trial

Journal of Traumatic Stress, EarlyView.
Abstract Written exposure therapy (WET) is an evidence‐based, trauma‐focused psychotherapy for posttraumatic stress disorder (PTSD) that has been tested with several trauma‐exposed samples. Although many individuals who receive WET and other trauma‐focused psychotherapies experience a significant reduction in PTSD symptoms, there remains room for ...
Casey L. Straud, Kiara H. Buccellato, Melissa Martinez, Stacey Young‐McCaughan, John C. Moring, Sarah Barron, Flavia R. Carreno, Daniel Lodge, David A. Morilak, Brian P. Marx, Denise M. Sloan, Alan L. Peterson, for the STRONG STAR Consortium   +12 more
wiley   +1 more source

Dorsal prefrontal cortex drives perseverative behavior in mice. [PDF]

Nat Commun
Lebedeva A, Wang Y, Funnell L, Terry B, Oh YJ, Miller K, Harris KD.   +6 more
europepmc   +1 more source

Associations between psychological distress symptoms and cognitive function among trauma‐exposed women: Moderating role of the developmental period of trauma exposure

Journal of Traumatic Stress, EarlyView.
Abstract Posttraumatic stress disorder (PTSD) and related internalizing symptoms, including anxiety and depression, are associated with emotional–cognitive alterations. These alterations, such as biased attentional processing and reduced emotional inhibition, are thought to contribute to persistent distress.
Myriam Beaudin, Catherine Raymond, Alexe Bilodeau‐Houle, Valérie Bouchard, Marie‐France Marin   +4 more
wiley   +1 more source

Interhemispheric Metabolic Effects of Transcranial Infrared Laser Stimulation of the Prefrontal Cortex. [PDF]

Hum Brain Mapp
O'Connor P, Lime T, Barrett DW, Huang LD, Gonzalez-Lima F.   +4 more
europepmc   +1 more source

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers, Zachery R. Gregorich, Megan S. Gant, Zhan Gao, Julia Chamot‐Rooke, Ying Ge   +5 more
wiley   +1 more source

Developmental alcohol exposure: Impacts on medial prefrontal cortex morphology and the excitatory-inhibitory balance. [PDF]

Prog Neuropsychopharmacol Biol Psychiatry
Cirafesi CK, Karkhanis AN, Diaz MR.
europepmc   +1 more source

Apathy in Parkinson's Disease: Distinguishing Overlapping Symptoms Via Network Analysis

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Anxiety, fatigue, and excessive daytime sleepiness (EDS) frequently co‐occur in Parkinson's disease (PD) and can influence the clinical determination of apathy. Objective To distinguish patient‐reported apathy from other non‐motor symptoms.
Joseph Seemiller, Abhimanyu Mahajan, Christopher B. Morrow, Joseph F. McGuire, Dawn Bowers, Kelly A. Mills, Gregory M. Pontone   +6 more
wiley   +1 more source

7 T MRI Connectivity‐Guided Reprogramming Improves Deep Brain Stimulation Motor Outcome in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established treatment for Parkinson's disease (PD). Using 7‐Tesla (7 T) MRI connectivity analysis to visualize the patient‐specific STN motor subdivision, we hypothesize that reprogramming patients who are stimulated outside of this subdivision can improve their ...
Yarit Wiggerts, Annabel van der Weide, Rick Schuurman, Pepijn van den Munckhof, Rob MA de Bie, Martijn Beudel, Maarten Bot   +6 more
wiley   +1 more source