Results 41 to 50 of about 1,105,698 (198)

Polyhalogenated Carbazole Impairs Dopaminergic Neurons through Dysregulation of Liquid–Liquid Phase Separation in Caenorhabditis elegans

Advanced Science, EarlyView.
Polyhalogenated carbazoles (PHCZ), persistent environmental contaminants, preferentially accumulate in neuronal tissues. Studies using Caenorhabditis elegans and human neuronal cell lines reveal that PHCZ induce dopaminergic neurodegeneration by promoting liquid–liquid phase separation of α‐synuclein, reducing condensate fluidity, impairing ...
Yuhang Luo, Hongbo Xu, Pei Peng, Xinhe Lu, Qian Zhou, Ziqing Gao, Cheng Tang, Hongyan Yin, Ying Cai, Gaga Mahai, Zhiqiang Zhu, Zuojun Liu, Hanzeng Li, Shunqing Xu   +13 more
wiley   +1 more source

A case report of heterochronic presentation of a bilateral tubal pregnancy

Clinical Case Reports, 2023
Key Clinical Message This paper highlights that diagnosis and treatment of one ectopic pregnancy does not rule out the happening of a second ectopic pregnancy in the same patient concurrently, especially if the patient has rising β‐hCG and persistent ...
Zeinab Mansouri, Azam Tarafdari, Sepideh Azizi, Bahareh Mehdikhani, Amirali Shababi, Farzad Vaghef Davari   +5 more
doaj   +1 more source

Temporal trends in severe morbidity and mortality associated with ectopic pregnancy requiring hospitalisation in Washington State, USA: a population-based study

BMJ Open, 2019
Objective To examine temporal trend in maternal mortality/severe morbidity associated with hospitalisation due to ectopic pregnancy. Design A population-based observational study.
S. Lisonkova, Justin Tan, Q. Wen, L. Abdellatif, Lindsay L Richter, Sukainah Alfaraj, P. Yong, M. Bedaiwy   +7 more
semanticscholar   +1 more source

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

Advanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu, Anwen Yin, Xiang Yu, Mingxin Wang, Jiahui Zhang, Kerong Liu, Yutong Hou, Minkai Cao, Yiting Zhang, Xiaoxiao Zhang, Yao Gao, Xirong Guo, Le Zhang, Yun Li   +13 more
wiley   +1 more source

Molar Ectopic Pregnancy after Tubectomy [PDF]

Acta Medica Iranica, 2012
Tubal ectopic hydatidiform mole is an uncommon but very important complication of pregnancy. The clinical manifestation is the same as ectopic pregnancy and in all of the cases management was the same as tubal ectopic pregnancy.
Zahra Heidar, Fateme Sadat Sarfjoo, Shahrzad Zademodares, Malihe Habibollahi, Neda Kheiri   +4 more
doaj   +2 more sources

Cesarean section scar ectopic pregnancy - a management conundrum: a case report

Journal of Medical Case Reports, 2019
BackgroundCesarean section scar ectopic pregnancies are a rare complication of pregnancy that may follow previous hysterotomy for any cause, uterine manipulation, and in vitro fertilization.
Rumbidzai Majangara, M. Madziyire, C. Verenga, M. Manase   +3 more
semanticscholar   +1 more source

5‐Hydroxymethylcytosine Dynamics Reveals Coordinated Reprogramming of Parental Genomes and X Chromosome Dosage Balance in Mouse SCNT Embryos

Advanced Science, EarlyView.
Genome‐wide, high‐resolution profiling of hydroxymethylation in mouse SCNT embryos reveals a transient, allele‐symmetric 5hmC reprogramming pattern distinct from natural embryos, with X‐chromosomes and imprinting control regions resistant to proper remodeling.
Zeming Xiang, Rui Yan, Jing Guo, Mengyao Wang, Xin Cheng, Fan Zhang, Tianzi Guo, Xin Long, Fan Guo, Dan Liang   +9 more
wiley   +1 more source

Role of ultrasound and color Doppler in diagnosis of ectopic pregnancy and to differentiate from corpus luteum cyst of pregnancy

Asian Journal of Medical Sciences
Background: Ectopic pregnancy is the leading cause of direct maternal deaths. Ectopic pregnancy and corpus luteum cyst are two most common differential diagnoses in a patient with urine pregnancy test (UPT) positive and no sonographic evidence of ...
Pooja Chowdary , Anilkumar Sakalecha , Anees Dudekula , Madan Kumar KN   +3 more
doaj   +1 more source

MSC Membrane‐Coated circPROSC‐siRNA Nanoparticles for Ameliorating Craniosynostosis by Inhibiting Premature Suture Ossification

Advanced Science, EarlyView.
CircPROSC promotes craniosynostosis by sponging miR‐6815‐5p, thereby activating WNT3A/β‐catenin signaling and enhancing RUNX2‐mediated osteogenesis. Targeted silencing of circPROSC with MSC membrane–coated siRNA nanoparticles (MM@Lipo/si‐circPROSC) delivered postnatally into cranial sutures attenuates premature suture closure in Twist1+/– mice ...
Zhenkun Weng, Xiu Chen, Jin Xu, Qing Yan, Jian Jiao, Qian Liu, Aihua Gu   +6 more
wiley   +1 more source

A Transmembrane Protein WAI‐B2 Confers Multiple Disease Resistance in Wheat by Activating Autoimmunity

Advanced Science, EarlyView.
Wheat production is under threat from multiple diseases. This study clones the wheat autoimmunity gene WAI‐B2 from an EMS‐induced mutant that encodes a distinct transmembrane protein conferring resistance to wheat rusts and powdery mildew ‐ two major diseases affecting wheat crops.
Wenling Li, Yongxing Chen, Lei Dong, Guanghao Guo, Huaizhi Zhang, Tao Shen, Gaojie Wang, Lingli Dong, Ping Lu, Miaomiao Li, Dan Qiu, Keyu Zhu, Beibei Li, Yikun Hou, Xuejia Cui, Baoge Huang, Fugang Yang, Hongkui Fu, Delin Li, Zhan Li, Jinghuang Hu, Yunfeng Qu, Huanhuan Lou, Shisheng Chen, Zaifeng Li, Ling Kang, Wuyun Yang, Chengguo Yuan, Hongjie Li, Yusheng Zhao, Zhiyong Liu, Haiyan Jia, Qiuhong Wu   +32 more
wiley   +1 more source