Results 51 to 60 of about 1,105,698 (198)

Integrated ERK‐PKA‐YAP/TAZ‐SHH Signaling Orchestrates Cortical Radial Glia Identity and Lineage Diversification

Advanced Science, EarlyView.
This study shows that ERK/PKA upregulation in mammalian cortical radial glia (RGs) sustains neurogenesis and suppresses gliogenesis. YAP/TAZ activation promotes ependymal cell formation, while enhanced SHH‐SMO signaling induces astrocyte, oligodendrocytes, and olfactory bulb interneuron generation.
Zhuangzhi Zhang, Zhejun Xu, Tongye Fu, Jialin Li, Feihong Yang, Chuannan Yang, Wenhui Zheng, Zizhuo Sha, Yanjing Gao, Mengge Sun, Zhenmeiyu Li, Jing Ding, Xiaosu Li, Zhengang Yang   +13 more
wiley   +1 more source

Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis‐Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish

Advanced Science, EarlyView.
Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi, FuMing Lai, Zheng Shen, XiaoYan Zhang, HanFei Wang, WenYe Liu, YunLong Wang, KuanYu Li, GuoLiang Li, YaPing Fang, Jing‐Xia Liu   +10 more
wiley   +1 more source

GSK3β‐Regulated Lipolysis is Required for Histone Acetylation and Decidualization in Early Pregnancy

Advanced Science, EarlyView.
Uterine Gsk3b knockout impairs decidual cell terminal differentiation by causing lipid droplet accumulation. GSK3β phosphorylates RNF213 to promote its lysosomal degradation, thereby enhancing lipolysis. The released fatty acids undergo β‐oxidation to generate acetyl‐CoA, which modulates histone acetylation and regulates decidual cell terminal ...
Peiran Wang, Yedong Tang, Xueling Zhao, Yu Ni, Hualan Zhou, Enhao Zhang, Gaizhen Li, Han Cai, Yinan Wang, James R. Woodgett, Wenbo Deng, Haibin Wang, Zhongxian Lu, Haili Bao, Shuangbo Kong   +14 more
wiley   +1 more source

Risk Factors for Recurrent Ectopic Pregnancy: A Case - Control Study

Gynecology Obstetrics & Reproductive Medicine, 2014
OBJECTIVES: To investigate the role of epidemiological factors in recurrent ectopic pregnancies. STUDY DESIGN: From January 2003 to February 2005, 205 women with single ectopic pregnancy and 20 women with recurrent ectopic pregnancy were identified. The
Abdullah Karaer, Sabri Cavkaytar, İsmail Mert, Sertaç Batıoğlu   +3 more
doaj  

Cidea Targeting Protects Cochlear Hair Cells and Hearing Function From Drug‐ and Noise‐Induced Damage

Advanced Science, EarlyView.
Acquired sensorineural hearing loss is primarily caused by the damage or loss of cochlear hair cells, induced by factors such as noise exposure and ototoxic drugs. The deficiency of apoptosis‐inducing gene Cidea in Cidea KO mice or by delivering CRISPR/SlugCas9‐HF via AAV to edit Cidea effectively alleviated hair cell damage and hearing loss caused by ...
Shasha Zhang, Ruiying Qiang, Yuan Zhang, Jinxian Wan, Chen Tao, Ying Dong, Xujun Tang, Li Xu, Hairong Xiao, Yanqin Lin, Wei Tong, Ying Ma, Yongming Wang, Peng Li, Renjie Chai   +14 more
wiley   +1 more source

Diagnostic Dilemma in Ovarian Pregnancy: A Case Series [PDF]

Journal of Clinical and Diagnostic Research, 2015
Ovarian pregnancy is a rare form of ectopic pregnancy but it is the most common type of nontubal ectopic pregnancy. Many times it is operated with a misdiagnosis of ruptured tubal ectopic pregnancy or hemorrhagic corpus luteum.
Jasmina Begum, P.Pallavee, Sunita Samal
doaj   +1 more source

A Novel Missense Variant in LMX1A Leads to Autosomal Dominant Nonsyndromic Hearing Loss

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Hereditary nonsyndromic hearing loss (NSHL) is a prevalent entity associated with over 150 known causative genes, including LMX1A, which has fewer than 10 reported pathogenic variants. Here we present a novel missense variant in LMX1A in a family of European descent with hereditary hearing loss. Clinical and family histories were obtained, and
Ryan Chen, Dayna Morel Swols, Guney Bademci, Mustafa Tekin   +3 more
wiley   +1 more source

MicroRNAs as Potential Serum Biomarkers for Early Detection of Ectopic Pregnancy

Cureus, 2018
Diagnosis of ectopic pregnancy relies on both ultrasound findings and human chorionic gonadotropin (hCG) measurements but due to the need for serial tests, tubal rupture and death represent major maternal and fetal risks.
E. Kontomanolis, Sofia Kalagasidou, Z. Fasoulakis   +2 more
semanticscholar   +1 more source

Development of the occipitopetrosal junctions: A histological study using human fetuses

The Anatomical Record, EarlyView.
Abstract The temporal bone petrosa is connected to the occipital bone at two sites: one junction with the basilar part (medial junction) and another with the lateral part (lateral junction). Using histological specimens from 45 human fetuses (approximately 7–39 weeks of gestational age or GA), we aimed to describe possible changes in histology and ...
Ai Hirano‐Kawamoto, Yohei Honkura, Chun‐Ai Li, Samuel Verdugo‐López, Gen Murakami, Jose Francisco Rodríguez‐Vázquez, Yukio Katori   +6 more
wiley   +1 more source

Point-of-care Ultrasound for the Diagnosis of Ectopic Pregnancy

Journal of Education and Teaching in Emergency Medicine, 2017
History of present illness: A 31-year-old female presented to the Emergency Department by ambulance with severe abdominal pain and presyncope. On exam, the patient was hypotensive with suprapubic tenderness. Though the patient denied being pregnant, her
Ahmed Farhat, Jessica Hoffmann, Maili Alvarado   +2 more
doaj   +1 more source