Results 31 to 40 of about 472,631 (218)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Influence of Pregnancy in Multiple Sclerosis and Impact of Disease-Modifying Therapies

Frontiers in Neurology, 2021
Purpose of this Review: This article is a systematic review on the influence pregnancy has on multiple sclerosis and the resulting impact of disease-modifying therapies.Findings: Multiple sclerosis predominantly affects young women with a clinical onset ...
Isabella Laura Simone, Carla Tortorella, Alma Ghirelli   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Embarazo múltiple Multiple pregnancy

Medisan, 2012
Se presenta el caso clínico de una fémina con embarazo múltiple, obesa, hipertensa y con antecedente de riesgo obstétrico, quien estuvo durante más de una semana en el Hospital Materno de Palma Soriano hasta su traslado para el Ginecoobstétrico "Mariana ...
Irma Mercedes Tumbarell Villalón, Leyti María Abraham Dusté, Arelis Montes de Oca García   +2 more
doaj  

Developmental toxicity and programming alterations of multiple organs in offspring induced by medication during pregnancy

Acta Pharmaceutica Sinica B, 2023
Medication during pregnancy is widespread, but there are few reports on its fetal safety. Recent studies suggest that medication during pregnancy can affect fetal morphological and functional development through multiple pathways, multiple organs, and ...
Zhengjie Lu, Yu Guo, Dan Xu, Hao Xiao, Yongguo Dai, Kexin Liu, Liaobin Chen, Hui Wang   +7 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Theoretical Model of the Relationship between Single Embryo Transfer Rate and Multiple Pregnancy Rate in Japan

Journal of Pregnancy, 2012
The purpose of the present study was to examine the effect of single embryo transfer (SET) in assisted reproductive technology (ART) on the reduction of the multiple pregnancy rate.
Syuichi Ooki
doaj   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

MONOCHORIONIC MULTIPLE PREGNANCY

Акушерство, гинекология и репродукция, 2016
The article describes the concept of monochorionic multiple pregnancies, the relevance and epidemiology of the topic, as well as complications in pregnancy and delivery in monochorionic twins.
N. A. Makatsariya
doaj  

Multiple pregnancies, the myometrium and the role of mechanical factors in the timing of labour

Current Research in Physiology, 2023
Multiple pregnancy remains a relatively common occurrence, but it is associated with increased risks of adverse outcomes for the mother and her babies and presents unique challenges to healthcare providers.
Sarah Arrowsmith
doaj   +1 more source