Results 41 to 50 of about 958,522 (307)

Germline TP53 Mutations Causing Diamond–Blackfan Anemia: A French Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Diamond–Blackfan anemia is a rare congenital erythroblastopenia typically caused by mutations in ribosomal protein genes. Recently, gain‐of‐function mutations in TP53 have been identified as a novel cause of Diamond–Blackfan anemia. We report two French patients who both harbored a heterozygous TP53 deletion (NM_000546.5: c.1077delA; p ...
Rafael Moisan   +6 more
wiley   +1 more source

Multiple pregnancy. Case report.

open access: yesMedisur, 2009
We present a case of a 34-year-old white female patient, of rural origins, with a history of 3rd degree bronchial asthma and respiratory arrests for that cause, who has required several admissions in the ICU.
Práxedes Regla Rojas Quintana
doaj   +2 more sources

The Role of Mindfulness and Self Compassion Toward Depression Among Pregnant Women [PDF]

open access: yes, 2018
Pregnant women tend to experience depression during pregnancy. This can affect mothers and babies' health widely. Previous research has found that mindfulness and self-compassion can reduce depression in pregnant women in abroad, but it still no specific
Chairunnisa, A. (Alfira)   +2 more
core   +3 more sources

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Young mothers in care, contributing to the contemporary debate [PDF]

open access: yes, 2008
Teenage pregnancy has become a broad issue in contemporary society and has become a focus for concern for young women in or exiting the care system. The article draws on interviews with twenty-four young mothers in, or on the fringes of the care system ...
Aldgate J.   +10 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Didrogesteron use in multiple pregnancy [PDF]

open access: yesГинекология, 2015
Multiple pregnancy is a pregnancy of high risk, as it demands careful observation in highly specialized medical centers (regional perinatal centres), that possess required experience, material and technical potential and human resources.Aim of the study:
I O Bushtyreva   +4 more
doaj  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Ruptured ectopic pregnancy following a cycle of freeze-all in vitro fertilization: A case report

open access: yesCase Reports in Women's Health, 2018
Patients undergoing assisted reproduction are advised to abstain from intercourse to prevent the possibility of multiple pregnancy. If patients do not follow this advice, multiple dizygotic pregnancy or even a heterotopic pregnancy can result.
Alyssa Hamlin   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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