Results 51 to 60 of about 133,695 (306)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Outcomes after transabdominal cerclage in twin pregnancy with previous unsuccessful transvaginal cerclage.

PLoS ONE, 2020
Transabdominal cerclage (TAC) is reported to be effective for preventing preterm birth in women with unsuccessful transvaginal cerclage (TVC) history. However, TAC has rarely been performed in twin pregnancy given the lack of sufficient evidence and the ...
Ga-Hyun Son, Heejin Ham, Sung-Taek Park, So-Yeon Choi, Ji-Eun Song, Keun-Young Lee   +5 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Twin Reversed Arterial Perfusion: To Treat or Not? [PDF]

Journal of Clinical and Diagnostic Research, 2017
Acardiac twinning or Twin Reverse Arterial Perfusion (TRAP)-sequence is a rare complication of monochorionic twin pregnancy. Whether to start elective or therapeutic treatment in TRAP-sequence is still controversial.
Sunita Dubey, Meesha Verma, Poonam Goel, RPS Punia   +3 more
doaj   +1 more source

Novel Use of a Social-Media-Based Survey to Detect Regional Differences in Management of Monochorionic-Diamniotic Twins. [PDF]

, 2020
ObjectiveThis study aims to evaluate the utility of social media to distribute a patient survey on differences in management and outcomes of monochorionic-diamniotic (MCDA) pregnancies.Study designA cross-sectional survey was posted to an English ...
Afshar, Yalda, Han, Christina S, Holliman, Kerry, Kwan, Lorna, Liu, Hui, Paek, Bettina, Platt, Lawrence D, Pluym, Ilina D, Rao, Rashmi, Scibetta, Emily, Walker, Martin, Wong, Thalia   +11 more
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Laser therapy for twin–twin transfusion syndrome in a dizygotic monochorionic twin pregnancy: A case report

Taiwanese Journal of Obstetrics & Gynecology, 2021
Objective: A monochorionic dizygotic (MCDZ) twin is rare, especially when complicated with twin–twin transfusion syndrome (TTTS) and treated by laser therapy.
Yao-Lung Chang, Sheng-Yuan Su, An-Shine Chao, Shuenn-Dyh Chang, Wen-I. Lee, Ming-Chou Chiang   +5 more
doaj   +1 more source

Twin Pregnancy in a Woman with Uterus Didelphys [PDF]

, 2011
Uterus didelphys is one of the congenital uterine anomalies due to defective medial fusion of mullerian ducts. This anomaly is known to have poor reproductive outcome and women with this condition often have to be treated for infertility.
Bhattacharya, Sohini, Mistri, Pallab Kumar   +1 more
core   +1 more source

Antenatal atazanavir: a retrospective analysis of pregnancies exposed to atazanavir. [PDF]

, 2014
INTRODUCTION: There are few data regarding the tolerability, safety, or efficacy of antenatal atazanavir. We report our clinical experience of atazanavir use in pregnancy.
Anderson, J, Bradshaw, D, Brook, G, Byrne, L, Chan, SY, de Ruiter, A, Dhairyawan, R, Hawkins, D, Hay, P, Mandalia, S, Naftalin, C, Natha, M, Noble, H, Offodile, N, Perry, M, Poulton, M, Rodgers, M, Roedling, S, Samuel, M, Sarner, L, Shah, R, Short, CE, Smith, K, Taylor, G, Zhou, J   +24 more
core   +2 more sources