Results 31 to 40 of about 506,036 (266)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Intra-partum and perinatal outcomes in fetuses exhibiting ZigZag pattern on cardiotocography trace: a systematic review and meta-analysis

Journal of Perinatal Medicine
Historically, baseline fetal heart rate variability (FHRV) with an amplitude of greater than 25 beats per minute, and lasting for more than 30 min, was defined as the saltatory pattern.
Finadri Luca, Mappa Ilenia, Khalil Asma, Rizzo Giuseppe, Lucidi Alessandro, Di Mascio Daniele, Liberati Marco, Chandraharan Edwin, D’Antonio Francesco   +8 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Acute fatty liver disease in full-term pregnancy: a case report and review of the literature

Journal of Medical Case Reports
Background Cases of acute fatty liver of pregnancy are extremely rare but represent a serious complication as a life-threatening condition for both the mother and newborn in late-term pregnancy.
Phuc Nhon Nguyen, Quang Nhat Ho
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Global inequities in adverse pregnancy outcomes: what can we do?

AJOG Global Reports
The Health Equity Leadership & Exchange Network states that “health equity exists when all people, regardless of race, sex, sexual orientation, disability, socioeconomic status, geographic location, or other societal constructs, have fair and just ...
James M. Roberts, MD, Seye Abimbola, MBChB, PhD, Tracy L. Bale, PhD, Aluisio Barros, MD, PhD, Zulfiqar A. Bhutta, MBBS, PhD, Joyce L. Browne, MD, PhD, Ann C. Celi, MD, MPH, Polite Dube, PhD, Cornelia R. Graves, MD, Marieke J. Hollestelle, PhD, Scarlett Hopkins, BSN, MA, Ali Khashan, PhD, Koiwah Koi-Larbi, LLM, Eve M. Lackritz, MD, Leslie Myatt, PhD, Christopher W.G. Redman, MBBChir, Özge Tunçalp, MD, PhD, Sten H. Vermund, MD, Michael G. Gravett, MD   +18 more
doaj   +1 more source

Low increase in phenylalanine tolerance during pregnancies in PKU woman with high prepregnancy BMI and postconceptional initiation of diet: A case report

International Journal of Reproductive BioMedicine, 2019
Background Women with untreated phenylketonuria (PKU) are at an increased risk to have offspring with multiple abnormalities due to teratogenic effects of hyperphenylalaninaemia.
Joanna Żółkowska, Kamil Hozyasz, Ph.D.   +2 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Assessment of Technical Quality of Pregnancy Care in Shahid Chamran Health Centers in Tabriz, 2014 [PDF]

Taṣvīr-i salāmat, 2015
Background and Objectives : Technical quality of health care, compared with whatever is presented on the basis of scientific evidence as a standard service, is an important aspect of the quality in health services and everything  that  customer receives.
Hassan Almaspoor Khanghah, Roya Hasanzadeh, Gisoo Alizadeh, Roghayyeh Alibabaei, Leila Doshmangir   +4 more
doaj  

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source