Results 111 to 120 of about 278,902 (273)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Neonates with acute liver failure have higher overall mortality but similar posttransplant outcomes as older infants

Liver Transplantation, EarlyView., 2022
Abstract Neonatal acute liver failure (ALF) carries a high mortality rate; however, little data exist on its peritransplant hospital course. This project aimed to identify factors associated with outcomes in neonates with ALF using large multicenter databases.
Swati Antala, Bridget Whitehead, Justin Godown, Matt Hall, Anna Banc‐Husu, Estella M. Alonso, Sarah A. Taylor   +6 more
wiley   +1 more source

Does self-reported pregnancy loss identify women at risk of an adverse cardiovascular phenotype in later life? Insights from UK Biobank.

PLoS ONE, 2019
IntroductionCardiovascular disease (CVD) is more common in women who have had pregnancy complications such as spontaneous pregnancy loss. We used cross-sectional data from the UK Biobank Imaging Enhancement Study to determine whether pregnancy loss is ...
Einas Elmahi, Mihir M Sanghvi, Alexander Jones, Christina Y L Aye, Adam J Lewandowski, Nay Aung, Jackie A Cooper, José Miguel Paiva, Elena Lukaschuk, Stefan K Piechnik, Stefan Neubauer, Steffen E Petersen, Paul Leeson   +12 more
doaj   +1 more source

Pregnancy Complications and Long-Term Atherosclerotic Cardiovascular Disease Risk

Current Atherosclerosis Reports
Abstract Purpose of Review Discuss the relationship between pregnancy complications and long-term atherosclerotic cardiovascular disease (ASCVD) risk. Recent Findings A large body of research confirms an association between pregnancy complications and increased short and ...
Rabadia, Soniya V., Heimberger, Sarah, Cameron, Natalie A., Shahandeh, Negeen   +3 more
openaire   +2 more sources

GDF15 Is Elevated in Eating Disorders and Is Involved in the Gut‐Brain Axis via Ghrelin

European Eating Disorders Review, EarlyView.
ABSTRACT Objective GDF15 induces anorexia and visceral discomfort, regulating appetite, food intake and potentially metabolic responses. However, its role in eating disorders remains unexplored. Method A total of 145 participants were recruited (60 patients with anorexia nervosa, 20 with bulimia nervosa, 13 with binge eating disorder, 52 participants ...
Livio Tarchi, Giulia Brancolini, Sara Giachetti, Gaia Maiolini, Emanuele Cassioli, Eleonora Rossi, Gianluca Villa, Rachele Garella, Roberta Squecco, Paolo Rovero, Paolo Comeglio, Valdo Ricca, Francesco De Logu, Romina Nassini, Giovanni Castellini   +14 more
wiley   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Pregnancy related complications in women with hypertrophic cardiomyopathy: a nationwide population-based cohort study

BMC Cardiovascular Disorders
Background The impact of hypertrophic cardiomyopathy (HCM) on cardiovascular and obstetrical outcomes in pregnant women remains unclear, particularly in Asian populations.
Won Yeol Choi, Kyung-Taek Park, H. Kim, Jun Hwan Cho, Gina Nam, Joonhwa Hong, Dongwoo Kang, Jungkuk Lee   +7 more
semanticscholar   +1 more source

The Nutritional and Bioactive Components, Potential Health Function and Comprehensive Utilization of Hawthorn: A Review

Food Frontiers, EarlyView.
This review systematically and comprehensively analyzes hawthorn (Crataegus spp.), covering its bioactive constituents, properties, and processed products. ABSTRACT Hawthorn is widely cultivated in China, with excellent varieties and steadily increasing production.
Wenteng Yang, Quanhong Gao, Kun Ran, Mingyue Jiao, Xiaodan Fu, Zhenlin Han, Chao Liu, Ningyang Li   +7 more
wiley   +1 more source

Deciphering of nutritional profile, therapeutic potential, and networking of bioactive compounds of Moringa oleifera: A comprehensive review

Food Biomacromolecules, EarlyView.
The graphical abstract signifies the nutritional profile of various parts of the Moringa oleifera plant, including dried leaves, fresh leaves, leaf powder, seeds, and pods; along with it’s bioactive substance and protein profiling of aqueous concentrates derived from the fruit, seed, and leaf.
Rajesh Kumar, Sunita Khatak, Vandana, Adarsh Kumar Shukla, Surbhi Panwar, Ashwani Kumar   +5 more
wiley   +1 more source

Exercise Intervention to Mitigate the Cardiovascular Sequence of Pregnancy Complications

Cureus
Pregnancy issues such as gestational hypertension, preeclampsia, and gestational diabetes mellitus (GDM) are significant contributors to long-term cardiovascular diseases (CVDs) in women. Recent research has proved the impact of exercise on improving cardiovascular outcomes, particularly in women with pregnancy-related disorders.
Rawat, Anurag, Vyas, Kinnari
openaire   +1 more source