Clinical Pharmacology &Therapeutics, EarlyView.Real‐world evidence (RWE) derived from real‐world data (RWD) can complement randomized controlled trials (RCTs), yet the validity of RWD relative to RCT data remains insufficiently characterized. We obtained post hoc consent and linked individual participant data from the US‐based INVESTED trial (2016–2019) with Medicare fee‐for‐service claims (2012 ...
Hanseul Cho +12 more
wiley +1 more source
Reduced plasma epidermal growth factor levels reflect poor glycaemic status in type 2 diabetes. [PDF]
Endocr ConnectAlshammari Y +7 more
europepmc +1 more source
Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta
Clinical Pharmacology &Therapeutics, EarlyView.Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung +12 more
wiley +1 more source
Delayed primary closure versus subcutaneous suction drain with primary closure following contaminated laparotomy wound. [PDF]
BioinformationRoy A, Mondal P, Kumar R.
europepmc +1 more source
From Prediction to Decision Making: PBPK and QSP as Regulatory‐Grade NAMs
Clinical Pharmacology &Therapeutics, EarlyView.New approach methodologies (NAMs) encompass a diverse and rapidly evolving set of experimental and computational tools designed to generate human‐relevant mechanistic data for use in drug development and regulatory decision making. Experimental NAMs provide insights into drug disposition, pharmacological activity, and disease biology that are difficult
Karen Rowland Yeo, Piet H. van der Graaf
wiley +1 more source
Cardiovascular disease risk factors in young people with diabetes mellitus. [PDF]
Cardiovasc Diabetol Endocrinol RepYardimci MM.
europepmc +1 more source
Clinical and Experimental Dental Research, EarlyView.Abstract Background Family plays a significant role in children's dental and oral health (DOH) elements, such as children's DOH knowledge and practice, the development of children's dental fear and anxiety (DFA), children's dental visits, and children's DOH status.
Wisnu Fadila +5 more
wiley +1 more source
Euglycemic Diabetic Ketoacidosis: Clinical Suspicion and Diagnosis. [PDF]
Clin Med Insights Endocrinol DiabetesShukla R, Shrestha P, Khanal B, Regmi B.
europepmc +1 more source
Photo Quiz: Globose Yeast‐Like Forms With Multiple Peripheral Buds in Urine and Cervical Cytology
Diagnostic Cytopathology, EarlyView.ABSTRACT A 26‐year‐old immunocompetent woman with a history of noninvasive, low‐grade papillary urothelial carcinoma presented with persistent upper abdominal pain. Urine cytology, performed for bladder tumor surveillance, revealed globose, yeast‐like forms (10–30 μm) with thick walls and multiple narrowly attached peripheral buds in a “ship wheel ...
Adil Menon +2 more
wiley +1 more source
Clustering patterns of behavioral and metabolic risk factors for noncommunicable diseases in Iran: findings from a national STEPS survey. [PDF]
Glob Health ActionKharaghani MA +10 more
europepmc +1 more source