Results 231 to 240 of about 357,374 (288)

The EXPLAIN Study: Exploring Arthrogryposis Multiplex Congenita in Adults in Norway — A Description of Demographic, Medical, and Neurological Findings

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis Multiplex Congenita (AMC) encompasses several hundred conditions with diverse genetic, pathophysiological, and clinical origins. The overarching EXPLAIN study explores underlying causes and implications of AMC and represents the largest clinical cohort of adults with AMC reported to date.
My Vuong Hermansen, Kristin Ørstavik, Unni Steen, Mathias Toft, Cathrine Brunborg, Lena Lande Wekre   +5 more
wiley   +1 more source

Spatial Transcriptomics of Human Decidua Identifies Molecular Signatures in Recurrent Pregnancy Loss. [PDF]

Genomics Proteomics Bioinformatics
Sha Q, Yu Q, Chen K, Wang J, Wang F, Jiang C, Li Y, Tang M, Hou Y, Liu K, Chen K, Yang Z, Li S, Fang J, Luo S, Zheng X, Weng J, Qu K, Guo C.   +18 more
europepmc   +1 more source

Dosing Interval Extension of Dupilumab in CRSwNP: Five‐Year Real World Outcomes

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a persistent, often Type 2‐mediated inflammatory disease that markedly impairs quality of life. While dupilumab provides rapid improvement, there is limited evidence on long‐term outcomes beyond 2 years, and the clinical impact of dosing‐interval extension remains unclear.
Nicholas J. Campion, Dioni‐Pinelopi Petsiou, Florian C. Fally, Karina Berbalk, Noah F. Melamed, Aldine Tu, Christina Morgenstern, Fana Alem Kidane, Mohammed Zghaebi, Linda Liu, Minghao Pan, Tina J. Bartosik, Victoria Stanek, Katarina Gangl, Julia Eckl‐Dorna, Sven Schneider   +15 more
wiley   +1 more source

Chronic Endometritis and Recurrent Pregnancy Loss: A review of evidence and underlying mechanisms. [PDF]

JBRA Assist Reprod
Álvares FCC, Sousa FTR, Oliveira ECF.
europepmc   +1 more source

Differences in Biologic Clinical Trials for Chronic Rhinosinusitis With Nasal Polyps—Are We Comparing Apples With Oranges?

International Forum of Allergy &Rhinology, EarlyView.
Key Points In recent years, several biologics targeting Type 2 inflammation have been developed for treating chronic rhinosinusitis with nasal polyps (CRSwNP). These have been studied in registrational randomized controlled trials (RCTs), which vary in their patient populations, trial design, endpoints, geography, timing, or data‐handling processes ...
Marjolein Cornet, Peter W. Hellings, Martin Desrosiers, Martin Wagenmann, Richard Follows, Laura Walrave, Luz Adriana Jimenez, Lee Tombs, Dawn Edwards, Peter Howarth, Joseph K. Han   +10 more
wiley   +1 more source

Phenotype- and phase-directed immune interpretation in recurrent implantation failure and pregnancy loss: an integrative framework. [PDF]

Front Reprod Health
Elgheriany A.
europepmc   +1 more source

Emotional Burden of Olfactory Dysfunction: A Psychological Cluster Analysis from a Tertiary Smell and Taste Clinic

International Forum of Allergy &Rhinology, EarlyView.
Key Points The emotional burden of olfactory dysfunction bears distinct psychological profiles. Objective olfactory dysfunction findings do not reliably reflect patients' emotional burden. Olfactory‐related quality of life assessment may identify patient risk of emotional distress.
Tom Fischer, Keren Avirame, Idan Peled, Ella Hazan, Elinoy Herstain, Hen Chaushu, Nidal Muhanna, Avraham Abergel, Narin N. Carmel Neiderman   +8 more
wiley   +1 more source

Sex Hormones-Mediated Modulation of Immune Checkpoints in Pregnancy and Recurrent Pregnancy Loss. [PDF]

Int J Mol Sci
Zych M, Roszczyk A, Zakrzewska M, Zagożdżon R, Pączek L, Dąbrowski FA, Kniotek MJ.   +6 more
europepmc   +1 more source

Inflammatory Signatures Beyond Th1/Th2 Endotypes Provide Insights Into Postoperative Recurrence in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) represents a spectrum of inflammatory endotypes, driven by distinct T helper (Th) immune responses. The high rate of recurrent disease despite appropriate medical and surgical interventions highlights the need for improved characterization beyond the traditional type 2 and non‐type 2 phenotypes to better
Liyona Kampel, Narin N. Carmel, Shaun Edalati, Hen Chaushu, Forsan Jahshan, Yaniv Hadi, Timur Pestrikov, Leonor Leider Trejo, Nidal Muhanna, Avraham Abergel   +9 more
wiley   +1 more source

Guided internet-delivered compassion-focused therapy for women with recurrent pregnancy loss: A protocol of a randomized controlled trial. [PDF]

PCN Rep
Ito Y, Kawai Iwasaki Y, Asano K, Toshimitsu M, Sakakibara E, Yumura H, Kanamori Y, Kamo S, Doi SK, Sasaki N, Imamura K, Kumasawa K, Iriyama T, Nishi D.   +13 more
europepmc   +1 more source