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Recurrent pregnancy loss

Nature Reviews Disease Primers, 2020
Recurrent pregnancy loss is a distressing pregnancy disorder experienced by ~2.5% of women trying to conceive. Recurrent pregnancy loss is defined as the failure of two or more clinically recognized pregnancies before 20-24 weeks of gestation and includes embryonic and fetal losses. The diagnosis of an early pregnancy loss is relatively straightforward,
Dimitriadis, E, Menkhorst, E, Saito, S, Kutteh, WH, Brosens, JJ   +4 more
core   +7 more sources

Sporadic pregnancy loss and recurrent miscarriage [PDF]

Репродуктивная эндокринология, 2020
Progesterone is essential for the maintenance of pregnancy, and progesterone deficiency is associated with miscarriage. The subject of whether progesterone supplementation in early pregnancy can prevent miscarriage has been a long-standing research ...
A. Coomarasamy, A. J. Devall
doaj   +6 more sources

Chromosomal miscarriage and pregnancy outcomes in recurrent pregnancy loss [PDF]

Reproduction and Fertility
This prospective cohort study aimed to assess whether a history of embryonic chromosomal abnormality affects subsequent pregnancy outcomes in women with unexplained recurrent pregnancy loss.
Yuxin Yang, Xiaoran Zhang, Yingying Zhang, Miaoxian Ou, Can Wang, Youhui Lu, Lu Luo, Qiong Wang   +7 more
doaj   +2 more sources

A combination of the HLA-DRB1*03 phenotype and low plasma mannose-binding lectin predisposes to autoantibody formation in women with recurrent pregnancy loss

Frontiers in Immunology, 2023
IntroductionIt is documented that a series of autoantibodies can be detected with increased frequency in women with recurrent pregnancy loss (RPL) and they may impact the pregnancy prognosis negatively.
Caroline Nørgaard-Pedersen, Caroline Nørgaard-Pedersen, Rudi Steffensen, Ulrik Schiøler Kesmodel, Ulrik Schiøler Kesmodel, Ole Bjarne Christiansen, Ole Bjarne Christiansen   +6 more
doaj   +1 more source

Dysbiosis of the Human Oral Microbiome During the Menstrual Cycle and Vulnerability to the External Exposures of Smoking and Dietary Sugar

Frontiers in Cellular and Infection Microbiology, 2021
Physiological hormonal fluctuations exert endogenous pressures on the structure and function of the human microbiome. As such, the menstrual cycle may selectively disrupt the homeostasis of the resident oral microbiome, thus compromising oral health ...
Nagihan Bostanci, Maria Christine Krog, Maria Christine Krog, Luisa W. Hugerth, Luisa W. Hugerth, Zahra Bashir, Zahra Bashir, Emma Fransson, Emma Fransson, Fredrik Boulund, Fredrik Boulund, Georgios N. Belibasakis, Kristin Wannerberger, Lars Engstrand, Lars Engstrand, Henriette Svarre Nielsen, Henriette Svarre Nielsen, Henriette Svarre Nielsen, Ina Schuppe-Koistinen, Ina Schuppe-Koistinen   +19 more
doaj   +1 more source

Chronic Endometritis and Uterine Endometrium Microbiota in Recurrent Implantation Failure and Recurrent Pregnancy Loss

Biomedicines, 2023
The aim of this study was to evaluate whether chronic endometritis (CE) and uterine endometrium microbiota were associated with repeated implantation failures (RIFs) and recurrent pregnancy losses (RPLs).
Kanako Takimoto, Hideto Yamada, Shigeki Shimada, Yoshiyuki Fukushi, Shinichiro Wada   +4 more
doaj   +1 more source

Pregnancy loss is related to body mass index and prediabetes in early adulthood: Findings from Add Health

PLoS ONE, 2022
Pregnancy loss, including miscarriage and stillbirth, affects 15–20% of pregnancies in the United States (US) annually. Accumulating evidence suggests that pregnancy loss is associated with a greater cardiovascular disease (CVD) burden later in life ...
Yamnia I. Cortés, Shuo Zhang, Jon M. Hussey   +2 more
doaj   +2 more sources

Anti-Factor XII Autoantibodies in Patients with Recurrent Pregnancy Loss Recognize the Second Epidermal Growth Factor–Like Domain

TH Open, 2019
Summary Background Factor XII (FXII) deficiency and autoantibodies that bind to FXII (anti-FXII) have been described in patients with adverse pregnancy outcomes, including recurrent pregnancy loss.
Yoshihiro Sato, Toshitaka Sugi, Rie Sakai   +2 more
doaj   +1 more source

Assessment of In Vitro and In Silico Protocols for Sequence-Based Characterization of the Human Vaginal Microbiome

mSphere, 2020
The vaginal microbiome has been connected to a wide range of health outcomes. This has led to a thriving research environment but also to the use of conflicting methodologies to study its microbial composition.
Luisa W. Hugerth, Marcela Pereira, Yinghua Zha, Maike Seifert, Vilde Kaldhusdal, Fredrik Boulund, Maria C. Krog, Zahra Bashir, Marica Hamsten, Emma Fransson, Henriette Svarre Nielsen, Ina Schuppe-Koistinen, Lars Engstrand   +12 more
doaj   +1 more source

Phenome‐Wide Analysis of Short‐ and Long‐Run Disease Incidence Following Recurrent Pregnancy Loss Using Data From a 39‐Year Period

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background It is unclear how recurrent pregnancy loss (RPL) impacts disease risk and whether there is a difference in risk between women with or without a live birth before RPL (primary versus secondary RPL).
David Westergaard, Anna Pors Nielsen, Laust Hvas Mortensen, Henriette Svarre Nielsen, Søren Brunak   +4 more
doaj   +1 more source