Results 81 to 90 of about 471,153 (360)

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Malaria in pregnancy: the difficulties in measuring birthweight [PDF]

, 2011
Recommendations for interventions to control malaria in pregnancy are often based on studies using birthweight as the primary endpoint. Differences in birthweight may be attributable partly to methodological difficulties. We performed a structured search
F Nosten, AT Papageorghiou, Nosten, F., Rijken, JA, JA Rijken, McGready, R, Papageorghiou, A. T., Kennedy, S. H., McGready, R., GHA Visser, Visser, GH, Visser, G. H. A., Kennedy, SH, Rijken, M. J., Mcgready, Rose, R McGready, SH Kennedy, Rijken, MJ, Rijken, J. A., Nosten, F, Papageorghiou, AT, Kennedy, Stephen, MJ Rijken   +22 more
core   +2 more sources

Adverse pregnancy outcome and connective tissue disease: why is there a link? [PDF]

, 2020
It has been known for many years that there are risks associated with pregnancy for women with a range of established connective tissue diseases (CTD), especially systemic lupus erythematosus (SLE). These risks can have to do with the disease itself, the
D Ellwood, Ellwood, D
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Safety of Artemether-Lumefantrine Exposure in First Trimester of Pregnancy: An Observational Cohort. [PDF]

, 2014
There is limited data available regarding safety profile of artemisinins in early pregnancy. They are, therefore, not recommended by WHO as a first-line treatment for malaria in first trimester due to associated embryo-foetal toxicity in animal studies ...
Abdulla, Salim, Sigilbert Mrema, Dominic Mosha, Salim Abdulla, Sevene, Esperanca, Mosha, D., Mrema, Sigilbert, Mazuguni, F., Abdulla, S., Esperanca Sevene, Blaise Genton, Mosha, Dominic, Mazuguni, Festo, Festo Mazuguni, Sevene, E., Genton, B., Genton, Blaise, Mrema, S.   +17 more
core   +1 more source

Associations of maternal cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1(CDKAL1) gene variants with adverse pregnancy outcome in Chinese women

BMC Pregnancy and Childbirth
Objective To test associations of cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1 (CDKAL1) gene variants with the risk of adverse pregnancy outcome in Chinese women and whether the association was mediated by occurrence of ...
Shuoying Yue, Meng Su, Zihao Zhang, Jing Li, Junhong Leng, Weiqin Li, Jin Liu, Tao Zhang, Yijuan Qiao, Zhijie Yu, Gang Hu, Jun Ma, Xilin Yang, Hui Wang   +13 more
doaj   +1 more source

Maternal, Fetal and Newborn Outcome with Respect to Anemic Status of Women Admitted in Maternity Ward of BPKIHS

Journal of Gandaki Medical College, 2019
Background: Anemia is a common problem in pregnancy particularly in developing countries. In Nepal, the prevalence of anemia in pregnancy is 48%. It is defined by WHO as hemoglobin level less than 11gm/dL in pregnancy.
S Upadhyaya, N. Pokharel, M. Shrestha, P. Basnet   +3 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Pattern and Predictors of Weight Gain During Pregnancy Among HIV-1-Infected Women from Tanzania [PDF]

, 2003
Progression of HIV disease is often accompanied by weight loss and wasting. Gestational weight gain is a strong determinant of maternal and neonatal outcomes; however, the pattern and predictors of weight gain during pregnancy among HIV-positive women ...
Msamanga, Gernard, Antelman, Gretchen, Fawzi W., Wafaie, Villamor, Eduardo, Peterson E., Karen, Spiegelman, Donna   +5 more
core  

Chronic hypertension and adverse pregnancy outcome: a cohort study [PDF]

, 2017
Objective: To examine the association between chronic hypertension (CH) and a wide range of adverse pregnancy outcomes after adjustment for confounding factors in obstetric history and maternal characteristics.
N. Prodan, R. Akolekar, Panaitescu, A.M., A. M. Panaitescu, Akolekar, R., Nicolaides, K.H., A. Syngelaki, K. H. Nicolaides, Syngelaki, A., Prodan, N.   +9 more
core   +1 more source