Results 81 to 90 of about 758,723 (235)
Advanced Science, EarlyView.Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae +5 more
wiley +1 more source
Advanced Science, EarlyView.Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo +10 more
wiley +1 more source
BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells
Advanced Science, EarlyView.BOULE orchestrates stress granule disassembly in germ cells via a two‐pronged mechanism: it promotes G3BP1 ubiquitination by upregulating TRIM27, generating a signal for VCP/FAF2 recruitment, and it maintains G3BP1 and FAF2 protein levels. BOULE deficiency disrupts disassembly complex formation, leading to impaired heat shock granule clearance ...
Xin Li +8 more
wiley +1 more source
Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency
Advanced Science, EarlyView.How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen +10 more
wiley +1 more source
Termination of Pregnancy Law reform Act
, 2017 Termination of pregnancy factsheets to support health and medical practitioners.
Women?s Health Strategy
core
Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo
Advanced Science, EarlyView.As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao +12 more
wiley +1 more source
Mobile call termination in the UK [PDF]
, 2007 We discuss policy towards mobile call termination, illustrated by the 2002 Competition Commission enquiry into the UK mobile market. We present a model of the mobile market which includes both fixed-to-mobile and mobile-to-mobile call termination.
Wright, J. +5 more
core +1 more source
Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy
Advanced Science, EarlyView.ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin +8 more
wiley +1 more source
Knowledge of contraception and barriers to contraceptive use in women undergoing repeat termination of pregnancy [PDF]
, 2013 Includes abstract.
Essel, Kwabena
core +1 more source
Advanced Science, EarlyView.An optimized Cas9‐enriched nanopore sequencing workflow, combined with STRiker, enables simultaneous analysis of disease‐associated STR loci from patient blood. The nCATS–STRiker workflow detects repeat expansions, de novo repeat motifs, interruption patterns, and methylation in a single assay, improving the genetic diagnosis of previously undiagnosed ...
Seungbok Lee +11 more
wiley +1 more source