Results 101 to 110 of about 12,066 (219)

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Maternal Age and Elective Inductions of Labor in Nulliparous Patients: A Multicenter Cohort Study. [PDF]

Am J Perinatol
Sarker M, Noonan G, Canfield D, Poorman GW, Levy B, Edmundson P, Emeruwa U, Gyamfi-Bannerman C, Lamale-Smith L.   +8 more
europepmc   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Glycated CD59: a novel biomarker for gestational diabetes.

Endocr Rev
Toth Castillo M, Drayton Powell S, Biermann A, Torrey J, Luque-Fernandez MA, Halperin J.   +5 more
europepmc   +1 more source

Tuberculosis preventive therapy in postpartum women with HIV modifies <i>M. tuberculosis</i>-specific and nonspecific immune responses. [PDF]

Front Immunol
Yengkhom D, Montepiedra G, Masheto G, Wabwire D, Stranix-Chibanda L, Matubu A, Violari A, Theron G, Gupta A, Weinberg A.   +9 more
europepmc   +1 more source

The Role of High Cxcl11 Expression in Ovarian Dysfunction Through NF‐κB and AKT Pathways in a Thin Endometrium Mouse Model

iNew Medicine, EarlyView.
Thin endometrium upregulates Cxcl11, which polarizes ovarian macrophages via NF‐κB/AKT, impairing ovarian function. A new uter‐ovarian signaling axis is identified. ABSTRACT Objective Thin endometrium (TE) is a recognized cause of female infertility, primarily associated with impaired uterine receptivity.
Yulu Yang, Fei Tang, Zihan Meng, Yunxi Bao, Jujun Han, Xiaohua Jiang, Jianye Wang, Ying Wang, Zhaolian Wei   +8 more
wiley   +1 more source

15-Year Experience of Patch Testing during Pregnancy: Retrospective Case-Control Study from a Tertiary Israeli Center.

Dermatology
Hilewitz D, Trattner A, Noyman Y, Radinsky II, Ben Simon N, Galili E, Sherman S, Mimouni D, Snast I.   +8 more
europepmc   +1 more source

Deep phenotyping of infants and toddlers undergoing food oral immunotherapy (DINOSAUR): design and baseline characteristics of a prospective multi-omics cohort. [PDF]

Front Allergy
Schoos AM, Skov FR, Borge SV, Mak R, Wong T, Erdle SC, Sham HP, Vallance BA, Soller L, Chan ES.   +9 more
europepmc   +1 more source

Tofacitinib Regulates β‐Catenin Nuclear Translocation to Inhibit FLS Migration and Alleviate Clinical Symptoms of RA

iNew Medicine, EarlyView.
ABSTRACT Objective Tofacitinib is a Janus kinase (JAK) inhibitor approved for the treatment of moderate‐to‐severe rheumatoid arthritis (RA). However, its synovium‐related molecular mechanisms, particularly its regulatory effect on fibroblast‐like synoviocyte (FLS) migration, remain incompletely understood.
Shuqi Fang, Tianjing Zhang, Ling Hu, Ruijin Liu, Leyi Jia, Menglin Bai, Jiale Dong, Yuchen Zhao, Han Wang, Lei Zhang, Tao Li, Youcai Deng, Xianzheng Zhang, Lingling Zhang   +13 more
wiley   +1 more source

Prognostic value of antiphospholipid antibodies in pregnancy outcomes in systemic lupus erythematosus. [PDF]

RMD Open
Zhang X, Huang C, Liu L, Cui Y, Cai B, Shi X, Liu J, Tian X, Li M, Song Y, Zeng X, Zhao J, Chinese Research Committee of Pregnancy and Reproduction in Autoimmune Rheumatic Diseases (CHOPARD).   +12 more
europepmc   +1 more source