Results 141 to 150 of about 11,390 (175)

Development and Analytical Validation of a Laboratory‐Customized TaqMan‐MGB Probe Method for CYP2C19 Genotyping

Journal of Clinical Laboratory Analysis, EarlyView.
A laboratory‐customized, open‐sequence TaqMan‐MGB probe assay was developed for detecting CYP2C19*2 and CYP2C19*17 polymorphisms using dried blood spot‐derived DNA. The assay demonstrated allele‐specific discrimination, candidate LODs of 1.17 × 102 copies/μL for CYP2C19*2 and 0.94 × 103 copies/μL for CYP2C19*17, and repeatability with CVs below 10%. In
Yaqun Liu, Lianghui Chen, Xuanyi Zheng, Peikui Yang, Yicun Chen, Chengsong Xie, Zhenxia Zhang, Yuzhong Zheng   +7 more
wiley   +1 more source

Beyond Preeclampsia: Focal and Segmental Glomerulosclerosis Presenting as Nephrotic-Range Proteinuria During Pregnancy, A Clinical Case Report. [PDF]

Clin Case Rep
Ximena Rosario SA, Eva Elizabet CP.
europepmc   +1 more source

Application of Cell‐Free DNA Barcode‐Enabled Single‐Molecule Test for Non‐Invasive Prenatal Testing of α‐Thalassemia and β‐Thalassemia

Journal of Clinical Laboratory Analysis, EarlyView.
We evaluated the cfBEST assay for non‐invasive prenatal testing of α‐ and β‐thalassemia in 72 families. The assay correctly identified 88 of 93 fetal alleles, achieving an overall accuracy of 94.6%, a sensitivity of 94%, and a specificity of 95.35%, with 100% concordance with postnatal follow‐up.
Qin Liu, Na Ma, Wanglan Tang, Qianting Chen, Deguo Tang, Chunyan Zeng, Xiaofeng Wang, Hui Xi   +7 more
wiley   +1 more source

Identification of Maternal Serum Longitudinal Signatures Through Profiling of 96 Cytokines. [PDF]

Life (Basel)
Kolesnyk V, Sinnott C, Hartwich TMP, Gandhi F, Culhane J, Lundsberg L, Abdel-Razeq S, Mansolf M, Novo S, Grechukhina O, Yang-Hartwich Y.   +10 more
europepmc   +1 more source

Heavy Metal Mixture Exposure and Insulin Resistance in U.S. Adults: The Mediating Role of Systemic Inflammation

Journal of Clinical Laboratory Analysis, EarlyView.
In a nationally representative sample of 3042 U.S. adults from NHANES 2021–2023, blood lead, cadmium, and mercury, both individually and as a weighted quantile sum (WQS) mixture, were inversely associated with insulin resistance assessed by HOMA‐IR. Systemic inflammation, measured by high‐sensitivity C‐reactive protein (hs‐CRP), significantly mediated ...
Cai Zhang, Shidi Lin, Yu Lin
wiley   +1 more source

Early pregnancy is characterized by a significant decrease in the diversity of the oral microbiome and strong associations with lifestyle and conception method. [PDF]

J Oral Microbiol
Finkelstein S, Frishman S, Turjeman S, Shtossel O, Tikhonov E, Nuriel-Ohayon M, Pinto Y, Popova P, Tkachuk AS, Vasukova EA, Anopova AD, Agay-Shay K, Pustozerov EA, Pervunina TM, Grineva EN, Hod M, Schwartz B, Hadar E, Koren O, Louzoun Y.   +19 more
europepmc   +1 more source

Changes of CEA Diagnostic Performance Under the New Reference Interval Stratified by Age and Sex

Journal of Clinical Laboratory Analysis, EarlyView.
Our study included patients with lung cancer, breast cancer, and colorectal cancer and apparently healthy individuals, conducted a large case–control study to assess the effects of age and sex on serum concentrations and positive rates of CEA, established age‐ and sex‐stratified reference intervals using indirect methods.
Ke Zhang, Xiarui Ye
wiley   +1 more source

Isolated Positive Treponemal Test in Pregnancy and Placental Abnormalities Without Confirmed Syphilis Infection: A Case Report. [PDF]

Case Rep Infect Dis
Stiles E, Aldrich ML, Magid MS, Otto C, Rubenstein A.   +4 more
europepmc   +1 more source

Anti-Kp^a antibody: Getting to know a strange and dangerous specificity. [PDF]

Hematol Transfus Cell Ther
Santacruz MQ.
europepmc   +1 more source

Genetic Polymorphisms of Vitamin D Receptor and Immune-Metabolic Mechanisms in Recurrent Pregnancy Loss: Narrative Review. [PDF]

Biology (Basel)
Aimagambetova G, Nemr R, Atageldiyeva K, Almawi WY.   +3 more
europepmc   +1 more source