Results 181 to 190 of about 2,043,399 (338)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Coronavirus disease 2019 in pregnant women: a report based on 116 cases

American Journal of Obstetrics and Gynecology, 2020
Jie Yan, Juanjuan Guo, Cuifang Fan, J. Juan, Xuechen B. Yu, Jiafu Li, Ling Feng, Chunyan Li, Huijun Chen, Yuan Qiao, Di Lei, Chen Wang, Guoping Xiong, F. Xiao, Wen-cong He, Qiumei Pang, Xiaoling Hu, Suqing Wang, Dunjin Chen, Yuan-zhen Zhang, L. Poon, Huixia Yang   +21 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Can Virtual Reality Technology Reduce Anxiety Before a Cesarean Section in Primigravida Women?

Health Science Reports
Background The emotional strains associated with impending cesarean sections pose significant challenges for primigravida women, potentially exacerbating anxiety levels and impacting overall well‐being.
Parto Mohammadi, Kambiz Bahaadinbeigy, Roghayeh Ershad Sarabi, Khadijeh Moulaei, Moghadameh Mirzai, Sakineh Mirzaei Khalilabadi, Mohsen Zarei Hajiabadi   +6 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Increased prevalence of essential hypertension amongst Nigerian IBO Women of reproductive age?

International Journal of Medicine and Health Development, 1998
In a cross-sectional study of the blood pressure distribution of 542 healthy non-pregnant Nigerian women, the mean +2SD of the measured casual blood pressure was 133/90mmHg. The prevalence of hypertension amongst these women was 8.5%. The epidemiological
H E Onah, U Megafu, G C Iloabachie, J M Okaro   +3 more
doaj  

Psychological impact of coronavirus disease 2019 in pregnant women

American Journal of Obstetrics and Gynecology, 2020
G. Saccone, A. Florio, Federica Aiello, R. Venturella, M. C. De Angelis, M. Locci, G. Bifulco, F. Zullo, A. Di Spiezio Sardo   +8 more
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Revised recommendations for HIV testing of adults, adolescents, and pregnant women in health-care settings.

MMWR Recommendations and Reports, 2006
Kevin A. Fenton, B. Branson, H. H. Handsfield, Margaret A. Lampe, Robert S. Janssen, Allan W. Taylor, S. Lyss, Jill E. Clark   +7 more
semanticscholar   +1 more source