Results 171 to 180 of about 2,109,783 (360)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Prenatal Lead Exposure Risk Assessment by Vermont Maternity Care Providers [PDF]
, 2017 Introduction. One percent of women of childbearing age in the U.S. have blood lead levels ≥ 5 ug/dL, which are associated with maternal hypertension during pregnancy, neural tube and cardiac defects in infants, low birth weight, prematurity, and ...
Berkman, Amy M +8 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Effect of nose ringing and stocking rate of pregnant and lactating outdoor sows on exploratory behavior, grass cover and nutrient loss potential [PDF]
, 2006 Nose ringing of outdoor sows is practiced to reduce grass sward damage for environmental reasons but conflicts with natural behaviour considerations.
Eriksen, J. +4 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Revista Cubana de Estomatología, 2011 O conhecimento do risco de cárie na gravidez é essencial para um correto plano de tratamento com ações educativas e preventivas às mães para que possam cuidar adequadamente de sua saúde bucal e de seus filhos. Este estudo retrospectivo teve como objetivo
Tatiana Carolina De Aguiar +4 more
doaj
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
The Effort to Decrease Maternal and Child Mortality Rates Through Cultural Transformation [PDF]
, 2016 Maternal and infant mortality in Ende is still high, but research related a social science is rare. The cultural aspect and medical factors such as the lack of primary health care services are also play a role.
Kristianti, R. D. (Rani) +3 more
core
Pregnant subject vs. pregnant body
, 2011 V International Workshop on Science, Technology and Gender: "Bodies and Differences", organizado por el Research Project "Sciences and Technologies from the Body from a STS Perspective", Centro de Humanidades y Ciencias Sociales, Consejo Superior de Investigaciones Científicas, Madrid, 24-26 noviembre 2009.
openaire +1 more source