Results 91 to 100 of about 2,212,500 (210)

RICTOR Prevents Decidualization Disorder in Women With Advanced Maternal Age via Regulating FoxO1 Nuclear Export

Aging Cell, Volume 25, Issue 9, September 2026.
Advanced maternal age impairs uterine decidualization via downregulated RICTOR‐ATK3‐FoxO1 signaling. The RICTOR agonist MHY1485 rescues decidual defects, offering a therapy for age‐related pregnancy failure. ABSTRACT Miscarriage and abnormal embryonic development in women of advanced maternal age (AMA) are often associated with impaired decidualization.
Yifeng Lin, Jiwei Sun, Yue Ying, Dan Li, Yuewen Ying, Xilin Shen, Xiao Sun, Dan Zhang, Yiqing Wu, Runju Zhang   +9 more
wiley   +1 more source

Preimplantation diagnosis of genetic diseases

Journal of Postgraduate Medicine, 2010
One of the landmarks in clinical genetics is prenatal diagnosis of genetic disorders. The recent advances in the field have made it possible to diagnose the genetic conditions in the embryos before implantation in a setting of in vitro fertilization.
Adiga, S.K., Kalthur, G., Kumar, P., Girisha, K.M.   +3 more
openaire   +2 more sources

Clinical and molecular characterization of maturity onset-diabetes of the young caused by hepatocyte nuclear factor-4 alpha mutation: red flags for prediction of the diagnosis

Annals of Saudi Medicine, 2014
BACKGROUND AND OBJECTIVES: The prevalence of maturity-onset diabetes of the young (MODY) in Saudi population remains unknown, and data on molecular etiology of this condition is limited.
Sarar Mohamed, Susan Elkholy, Ebtessam El-Meleagy, Khaled Abu-Amero, Ali M. Hellani   +4 more
doaj   +1 more source

Preimplantation genetic diagnosis.

, 2010
Preimplantation genetic diagnosis (PGD) is the screening of embryos at the cleavage stage in order to select and transfer only the desired embryo. The main indications of PGD are monogenic disorders and aneuploidy.
Lalioti, M D
core  

‘When diagnostics become prevention’: A patient's perspective on Darier's disease

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Fauve C. A. P. van Veen, Silke M. J. C. J. Koster, Antoni H. Gostyński   +2 more
wiley   +1 more source

Effect of a maternal inflammatory challenge during the preimplantation period on offspring development and phenotype

, 2009
The preimplantation mammalian embryo is sensitive to its immediate surroundings: alterations to its in vitro or in vivo environment can affect not only the immediate events of blastocyst formation, but can also give rise to long-term phenotypic ...
Williams, Charlotte Lucy
core   +1 more source

Family planning and preimplantation testing: family experiences in congenital adrenal hyperplasia

Frontiers in Endocrinology
IntroductionPre-implantation testing (PGT) is often suggested by healthcare professionals (HCP) to parents of children with congenital adrenal hyperplasia (CAH) considering subsequent children.
Jessica L. Sandy, Jessica L. Sandy, Jessica L. Sandy, Grant Betts, Jessica L. Harper, Suzanne M. Nevin, Suzanne M. Nevin, Suzanne M. Nevin, Rebecca Deans, Rebecca Deans, Rebecca Deans, Kristen A. Neville, Kristen A. Neville   +12 more
doaj   +1 more source

Comparison of euploidy rates between progestin-primed ovarian stimulation and GnRH antagonist protocols: a single-center study in a mixed-ethnicity population

Frontiers in Endocrinology
ObjectiveTo compare the euploidy rate between ovulation suppression protocols using PPOS and GnRH-ant, and to evaluate possible variables associated with euploidy rate such as age, BMI, infertility duration, treatment-related factors, and semen ...
Caroline Ingold, Giovanna Giovacchini dos Santos, Caio Parente Barbosa, Renato De Oliveira   +3 more
doaj   +1 more source

Preimplantation FISH Diagnosis of Aneuploidies

, 2003
Preimplantation genetic diagnosis (PGD) has been introduced as a principally new approach to the prevention of genetic disorders, avoiding prenatal diagnosis and potential termination of pregnancy (1,2). It is based on the genetic testing of oocytes or embryos, with the purpose of establishing an unaffected pregnancy, rather than performing fetal ...
Yury, Verlinsky, Jeanine, Cieslak, Anver, Kuliev   +2 more
openaire   +2 more sources

Selective abortion after preimplantation sex selection: An ethical and legal issue in Indonesia

GHMJ (Global Health Management Journal), 2018
Background: The emerging of sex selection technology in Indonesia is sperm sorting, meanwhile sex selection with Preimplantation Genetic Diagnosis (PGD) methods is not widely used.
Pujiyono, Rani Tiyas Budiyanti
doaj