To Be or not to Be? A Critical Appraisal of the Welfare of Children Conceived through New Reproductive Technologies [PDF]
, 2008 Over three million children are believed to have been born worldwide - and over 200,000 annually - as a result of “new reproductive technologies” (NRTs).
Blyth, Eric
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Leveraging paired germline and somatic analysis to improve the classification of DDX41 variants
British Journal of Haematology, EarlyView.Summary Constitutional pathogenic variants in DDX41 predispose to myelodysplasia and acute myeloid leukaemia. Acquisition of subsequent somatic hits in the second allele is frequent, with notable recurrent variants at key hotspots. Sequencing of Deoxyribonucleic acid from blood/marrow of 239 patients with suspected/confirmed haematological malignancies
Andrew George +13 more
wiley +1 more source
Medična Informatika ta Inženerìâ, 2012 Application of the information technologies is becoming increasingly important in the practice of molecular and cytogenetic analysis of chromosomal abnormalities in particular on the preimplantation level.
S. V. Denysenko
doaj +1 more source
Abnormal cleavage patterns in equine in vitro‐produced embryos lead to higher early pregnancy loss
Equine Veterinary Journal, EarlyView.Summary Background Despite significant advances, in vitro production (IVP) of equine embryos continues to lack standardised embryo classification criteria and is associated with increased rates of early pregnancy loss compared with in vivo‐derived blastocysts.
Soledad Martin‐Pelaez +6 more
wiley +1 more source
Pre-implantation Genetic Diagnosis of Thalassemias
Thai Journal of Obstetrics and Gynaecology, 2018 Beta-Thalassemia major, beta-thalassemia-Hb E disease and Hb Bart’s disease are severe hereditary anemia which are prevalent in Thailand and neighborhood countries.
Wirawit Piyamongkol
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Embryos as Patients? Medical Provider Duties in the Age of CRISPR/Cas9 [PDF]
, 2017 The CRISPR/Cas9 genome engineering platform is the first method of gene editing that could potentially be used to treat genetic disorders in human embryos. No past therapies, genetic or otherwise, have been intended or used to treat disorders in existent
Powell, G. Edward, III
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The improvement of the best practice guidelines for preimplantation genetic diagnosis of cystic fibrosis: toward an international consensus [PDF]
, 2015 Cystic fibrosis (CF) is one of the most common indications for preimplantation genetic diagnosis (PGD) for single gene disorders, giving couples the opportunity to conceive unaffected children without having to consider termination of pregnancy. However,
Claustres, M +17 more
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Regretting mother‐ and fatherhood in Switzerland: Equal parenthood regret but for different reasons
Family Relations, EarlyView.Abstract Objective This article investigates the prevalence of and factors associated with parenthood regret in Switzerland. Background There is increasing evidence that parenthood regrets occur both in mothers and fathers, but little is known about their causes and how they relate to gendered norms and conditions of parenthood.
Larissa Fritsch, Sandra Gilgen
wiley +1 more source
Application of preimplantation genetic diagnosis in equine blastocysts [PDF]
SPERMOVA, 2016 Pre-implantation genetic diagnosis (PGD) is a procedure used to screen in vitroproduced embryos or embryos recovered after uterine flush to determine genetic traits by DNA testing prior to transfer into the uterus.
Grady ST, Hinrichs K
doaj +1 more source
L'incostituzionalità della diagnosi genética preimpianto [PDF]
, 2015 medically assisted procreation, preimplantation genetic diagnosis ...
Di Miele, Cinzia
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