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Preimplantation Genetic Diagnosis
Hemoglobin, 2009Couples at risk for having an affected child with homozygous thalassemia or other serious hemoglobin disorder have various options for prevention. The most used in some countries has been prenatal diagnosis with a choice of termination of pregnancy. A more recent addition is preimplantation genetic diagnosis (PGD).
J P M, Geraedts, G M W R, De Wert
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Preimplantation genetic diagnosis
Molecular and Cellular Endocrinology, 2000Preimplantation genetic diagnosis (PGD) includes a variety of techniques that have been developed to detect the transmission to the offspring of genetic diseases or of chromosome abnormalities by couples at risk before a pregnancy is established, to avoid these couples the risk of recurrent abortions and/or of repeated terminations of pregnancy ...
J, Egozcue +4 more
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Clinics in Perinatology, 2003
Preimplantation genetic diagnosis is a valuable addition to the repertoire of reproductive medicine because it gives individuals with a documented history of a genetic disorder the opportunity to begin a wanted pregnancy with little or no fear that they are transmitting this disorder to their offspring.
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Preimplantation genetic diagnosis is a valuable addition to the repertoire of reproductive medicine because it gives individuals with a documented history of a genetic disorder the opportunity to begin a wanted pregnancy with little or no fear that they are transmitting this disorder to their offspring.
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PREIMPLANTATION PRENATAL DIAGNOSIS
Obstetrics and Gynecology Clinics of North America, 1993Preimplantation prenatal diagnosis refers to the application of molecular genetic techniques to the assessment of gametes before conception or to early embryos before implantation. Such techniques could allow couples at significant risk for a variety of known genetic diseases to use assisted reproductive technology in achieving pregnancies that are ...
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Preimplantation genetic diagnosis
Current Opinion in Pediatrics, 1994Preimplantation genetic diagnosis now represents an alternative reproductive option for parents at high risk of having offspring affected with certain genetic diseases. Progress in the past year has included increasing reliability in embryo sexing by both polymerase chain reaction and fluorescent in situ hybridization techniques; delivery of babies ...
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FISH in Preimplantation Diagnosis
2003Analysis of chromosomes in human embryonic nuclei would ideally be achieved by karyotyping. Several studies have used this technique to examine human embryonic chromosomes (1-4), but information is limited, since it is difficult to obtain bandable metaphase spreads.
J C, Harper, J D, Delhanty
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Preimplantation Polar Body Diagnosis
Biochemical and Molecular Medicine, 1996Preimplantation polar body diagnosis makes it possible to detect and avoid genetic and chromosomal disorders before pregnancy. We have shown that the polar body biopsy does not affect fertilization and viability of the resulting embryos. Our present experience of polar body diagnosis includes 187 clinical cycles, performed for preimplantation diagnosis
Y, Verlinsky, A, Kuliev
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Preimplantation diagnosis of genetic disease
Current Opinion in Obstetrics and Gynecology, 1993Preimplantation diagnosis offers couples at high risk of transmitting a genetic disease the opportunity of prenatal diagnosis before the establishment of pregnancy. The successful application of embryo biopsy techniques, and of the polymerase chain reaction for the amplification of DNA, as well as fluorescent in-situ hybridization methods have allowed ...
A L, Muggleton-Harris, P R, Braude
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Preimplantation Genetic Diagnosis and Screening
Seminars in Reproductive Medicine, 2005Preimplantation genetic diagnosis (PGD) identifies genetic abnormalities in preimplantation embryos prior to embryo transfer. PGD is an exciting technology that may improve the likelihood of a successful pregnancy and birth for five distinct patient groups: (1) those with infertility related to recurrent miscarriages or unsuccessful in vitro ...
W G, Kearns +9 more
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In Vitro Fertilization and Preimplantation Diagnosis
1991The preimplantation diagnosis of genetic disorders became possible since the availability of in vitro fertilization technology, the advances made in the micromanipulation of gametes or embryos and the ultra-sensitive procedures to detect gene mutations. The purpose of this report is to analyze the actual performance and possibilities of three important
Devroey, Paul +4 more
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