Results 131 to 140 of about 3,344 (173)

Preimplantation Genetic Testing for Aneuploidy: A Review

Obstetrical & Gynecological Survey, 2019
Importance Preimplantation genetic testing for aneuploidy (PGT-A) has undergone many technical developments over recent years, including changes in biopsy timings, methodology, and genetic analysis techniques. The evidence surrounding the efficaciousness of PGT-A is sporadic and inconsistent; as such, significant doubt and ...
James M, Kemper, Beverley J, Vollenhoven, Alon J, Talmor   +2 more
openaire   +2 more sources

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Journal of Visualized Experiments, 2019
Chromosomal aneuploidy, one of the main causes leading to embryonic development arrest, implantation failure, or pregnancy loss, has been well documented in human embryos. Preimplantation genetic testing for aneuploidy (PGT-A) is a genetic test that significantly improves reproductive outcomes by detecting chromosomal abnormalities of embryos.
Baoheng, Gui, Yingxin, Zhang, Bo, Liang, Yvonne Ka Yin, Kwok, Wai Ting, Lui, Queenie Sum Yee, Yeung, Lingyin, Kong, Liming, Xuan, Jacqueline Pui Wah, Chung, Kwong Wai, Choy   +9 more
openaire   +2 more sources

[Preimplantation genetic testing for aneuploidy].

Ugeskrift for laeger, 2020
This review summarises the current knowledge on preimplantation genetic testing for aneuploidy (PGT-A). Selection and transfer of euploid embryos aim to improve live birth rate (LBR) per embryo transfer, but fluorescence in situ hybridisation-based PGT-A and biopsy of cleavage stage embryos in the 2000s was a disappointment, as studies revealed a ...
Viktoria, Holmqvist, Laura Kristine Soenderberg, Roos, Kristin Ros, Kjartansdottir, Morten, Dunø, Morten Rønn, Petersen, Christina, Hnida, Inge Søkilde, Pedersen, Anja, Ernst, Christian Liebst Frisk, Toft, Tue, Diemer, Hans Jakob, Ingerslev, Anja, Pinborg, Kristine, Løssl   +12 more
openaire   +1 more source

The impact of preimplantation genetic testing for aneuploidy on prenatal screening

Journal of Perinatal Medicine, 2021
Abstract Objectives To determine whether preimplantation genetic testing for aneuploidy (PGT-A) is associated with a reduced risk of abnormal conventional prenatal screening results in singleton pregnancies conceived using in vitro fertilization (IVF).
Moti Gulersen, Alexandra Peyser, Jiyoung Kim, Amanda Ferraro, Randi Goldman, Christine Mullin, Xueying Li, David Krantz, Eran Bornstein, Burton Rochelson   +9 more
openaire   +2 more sources

Preimplantation genetic testing for aneuploidy (PGT-A)—a single-center experience

Journal of Assisted Reproduction and Genetics, 2022
The aim of this study was to determine the prevalence and nature of human embryonic aneuploidy based on the preimplantation genetic testing for aneuploidy (PGT-A), the distribution of aneuploidy across the individual chromosomes, and their relationship to maternal age.This is a retrospective cohort study conducted at a single center. The study includes
Jiny Nair, Sachin Shetty, Cynthia Irene Kasi, Nirmala Thondehalmath, Deepanjali Ganesh, Vidyalakshmi R. Bhat, Sajana Mannadia, Anjana Ranganath, Rajsekhar Nayak, Devika Gunasheela, Swathi Shetty   +10 more
openaire   +2 more sources

Advances in Preimplantation Genetic Testing for Monogenic Disease and Aneuploidy

Annual Review of Genomics and Human Genetics, 2017
Genetic testing of preimplantation embryos promises to prevent monogenic disease in children born to at-risk couples, the transfer of unbalanced embryos to patients carrying a balanced translocation, and the use of aneuploid embryos created during in vitro fertilization.
Nathan R, Treff, Rebekah S, Zimmerman
openaire   +2 more sources

Impact of preimplantation genetic testing for aneuploidy on obstetrical practice

Current Opinion in Obstetrics & Gynecology, 2019
Purpose of review To provide updated information on preimplantation genetic testing for aneuploidy (PGT-A), focusing on its implications on prenatal diagnostic approaches after transferal of mosaic aneuploid embryos. Recent findings PGT-A is a technology to screen for chromosome ...
Yiu-Man, Chan, Tin-Chiu, Li, Liona C Y, Poon   +2 more
openaire   +2 more sources

The evolution of preimplantation genetic testing for aneuploidy

Reproductive BioMedicine Online, 2019
Abnormal chromosome number or aneuploidy has been recognised as a major contributor to implantation and pregnancy failure and miscarriage since the earliest years of IVF following the birth of Louise Brown forty years ago. Already in 1986, for example, Angell and colleagues, reported "Evidence was found of nondisjunction, resulting in trisomy, monosomy
openaire   +1 more source

Non-invasive preimplantation genetic testing for aneuploidy (NIPGT-A)

Reproductive BioMedicine Online, 2019
Introduction Preimplantation genetic testing without trophectoderm (TE) biopsy is an attractive approach to avoid any potential risk due to an invasive procedure.The overriding goalof the non- invasive preimplantation genetic testing (NIPGT) is to utilize the cell free embryonic DNA (cfeDNA) in assessment of chromosomal status of the embryo (NIPGT-A).
Kuznyetsov Valeriy, Madjunkova Svetlana, Antes Ran, Abramov Rina, Motamedi Gelareh, Ibarrientos Zenon, Chen Siwei, Clifford Librach   +7 more
openaire   +1 more source

Preimplantation Genetic Testing for Aneuploidy

assess the accuracy and effectiveness of preimplantation genetic testing for aneuploidy (PGT-A) on frozen embryos using conventional IVF (c-IVF) insemination ...
openaire   +1 more source